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RIPK1 [cytosol]
Stable Identifier
R-GGA-168651
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
E1C526
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Innate Immune System (Gallus gallus)
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88-independent TLR4 cascade (Gallus gallus)
TRIF (TICAM1)-mediated TLR4 signaling (Gallus gallus)
IKK complex recruitment mediated by RIP1 (Gallus gallus)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Gallus gallus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Gallus gallus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TRIF-mediated programmed cell death (Gallus gallus)
Caspase-8 processing within TLR4 complex (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TLR4-induced ripoptosome assembly (Gallus gallus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Deubiquitination (Gallus gallus)
Ovarian tumor domain proteases (Gallus gallus)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Gallus gallus)
TNFAIP3:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNFAIP3 (A20) ubiquitinates RIPK1 (Gallus gallus)
TNFAIP3:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
Ub-specific processing proteases (Gallus gallus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Gallus gallus)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
Programmed Cell Death (Gallus gallus)
Apoptosis (Gallus gallus)
Caspase activation via extrinsic apoptotic signalling pathway (Gallus gallus)
Caspase activation via Death Receptors in the presence of ligand (Gallus gallus)
Caspase-8 processing within TLR4 complex (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
Dimerization of procaspase-8 (Gallus gallus)
TNF-mediated dimerization of procaspase-8 (Gallus gallus)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
Regulation by c-FLIP (Gallus gallus)
Caspase-8 and FLIP(L) processing at DISC (Gallus gallus)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Gallus gallus)
DISC [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
DISC [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Gallus gallus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
Regulated Necrosis (Gallus gallus)
RIPK1-mediated regulated necrosis (Gallus gallus)
Regulation of necroptotic cell death (Gallus gallus)
CASP8 activity is inhibited (Gallus gallus)
FLIP(L) and procaspase-8 form heterodimer (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
DISC [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
DISC [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
FLIP(S) and procaspase-8 form heterodimer (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
DISC [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
DISC [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
RIPK1 is cleaved by CASP8 (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Death Receptor Signaling (Gallus gallus)
TNF signaling (Gallus gallus)
Regulation of TNFR1 signaling (Gallus gallus)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Gallus gallus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Gallus gallus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
K63polyUb-RIPK1 is deubiquitinated (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
MAPKAPK2 phosphorylates RIPK1 at S320 (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
RIPK1 binds STUB1 (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
RIPK1 is cleaved by CASP8 (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
RIPK1 is cleaved by CASP8:FLIP(L) (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Gallus gallus)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Gallus gallus)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Gallus gallus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
ULK1 phosphorylates RIPK1 at S357 (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNFR1-induced NF-kappa-B signaling pathway (Gallus gallus)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNFR1-induced proapoptotic signaling (Gallus gallus)
TRADD:TRAF2:RIP1 binds FADD (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:E1C526
Reference Genes
ENSEMBL:ENSGALG00000012827
UCSC:E1C526
Participates
as a component of
TNFAIP3:RIPK1 [cytosol] (Gallus gallus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Gallus gallus)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Gallus gallus)
as a member of
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Gallus gallus)
as an input of
RIPK1 binds STUB1 (Gallus gallus)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Gallus gallus)
Other forms of this molecule
K48polyUb-RIPK1 [cytosol]
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
K63,M1polyUb-RIPK1 [cytosol]
RIPK1(1-324) [cytosol]
RIPK1(325-671) [cytosol]
polyUb-K377,K604,K634-RIPK1 [cytosol]
phospho-K63,M1polyUb, p-T189-RIPK1 [cytosol]
phospho-p-S320-RIPK1 [cytosol]
phospho-p-S357-RIPK1 [cytosol]
phospho-p-S166-RIPK1 [cytosol]
K63polyUb-RIPK1 [cytosol]
Inferred From
RIPK1 [cytosol]
(Homo sapiens)
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