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RIPK1 [cytosol]
Stable Identifier
R-GGA-168651
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
RIPK1, E1C526
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Innate Immune System (Gallus gallus)
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88-independent TLR4 cascade (Gallus gallus)
TRIF(TICAM1)-mediated TLR4 signaling (Gallus gallus)
IKK complex recruitment mediated by RIP1 (Gallus gallus)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Gallus gallus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Gallus gallus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TRIF-mediated programmed cell death (Gallus gallus)
Caspase-8 processing within TLR4 complex (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TLR4-induced ripoptosome assembly (Gallus gallus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Deubiquitination (Gallus gallus)
Ovarian tumor domain proteases (Gallus gallus)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Gallus gallus)
TNFAIP3:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNFAIP3 (A20) ubiquitinates RIPK1 (Gallus gallus)
TNFAIP3:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
Ub-specific processing proteases (Gallus gallus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Gallus gallus)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
Programmed Cell Death (Gallus gallus)
Apoptosis (Gallus gallus)
Caspase activation via extrinsic apoptotic signalling pathway (Gallus gallus)
Caspase activation via Death Receptors in the presence of ligand (Gallus gallus)
Caspase-8 processing within TLR4 complex (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
Dimerization of procaspase-8 (Gallus gallus)
TNF-mediated dimerization of procaspase-8 (Gallus gallus)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
Regulation by c-FLIP (Gallus gallus)
Caspase-8 and FLIP(L) processing at DISC (Gallus gallus)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Gallus gallus)
DISC [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
DISC [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Gallus gallus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
Regulated Necrosis (Gallus gallus)
RIPK1-mediated regulated necrosis (Gallus gallus)
Regulation of necroptotic cell death (Gallus gallus)
CASP8 activity is inhibited (Gallus gallus)
FLIP(L) and procaspase-8 form heterodimer (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
DISC [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
DISC [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
FLIP(S) and procaspase-8 form heterodimer (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
DISC [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
DISC [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
RIPK1 is cleaved by CASP8 (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Death Receptor Signalling (Gallus gallus)
TNF signaling (Gallus gallus)
Regulation of TNFR1 signaling (Gallus gallus)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Gallus gallus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Gallus gallus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
RIPK1 is cleaved by CASP8 (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
RIPK1 is cleaved by CASP8:FLIP(L) (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
RIPK1 is deubiquitinated (Gallus gallus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Gallus gallus)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Gallus gallus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Gallus gallus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Gallus gallus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNFR1-induced NFkappaB signaling pathway (Gallus gallus)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Gallus gallus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Gallus gallus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TNFR1-induced proapoptotic signaling (Gallus gallus)
TRADD:TRAF2:RIP1 complex binds FADD (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIPK1 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:E1C526
Gene Names
RIPK1
Reference Genes
BioGPS Gene:378921 RIPK1
ENSEMBL:ENSGALG00000012827
Monarch:378921 RIPK1
NCBI Gene:378921 RIPK1
Reference Transcript
RefSeq:XM_015275819.1 RIPK1
RefSeq:XM_015275818.1 RIPK1
Other Identifiers
378921
GO:0000278
GO:0001934
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0005123
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0006464
GO:0006468
GO:0006810
GO:0006915
GO:0006950
GO:0007049
GO:0007165
GO:0008150
GO:0008219
GO:0008283
GO:0009056
GO:0009058
GO:0010940
GO:0016301
GO:0019899
GO:0022607
GO:0030154
GO:0031264
GO:0031625
GO:0032757
GO:0032760
GO:0032991
GO:0034612
GO:0034641
GO:0036289
GO:0040007
GO:0042327
GO:0042802
GO:0042803
GO:0043065
GO:0043066
GO:0043068
GO:0043123
GO:0043124
GO:0043167
GO:0043226
GO:0043235
GO:0043410
GO:0044257
GO:0044877
GO:0045651
GO:0045944
GO:0046330
GO:0046777
GO:0048856
GO:0050729
GO:0051092
GO:0055085
GO:0060044
GO:0060545
GO:0060546
GO:0065003
GO:0070105
GO:0070231
GO:0070266
GO:0070301
GO:0070513
GO:0070926
GO:0071356
GO:0071363
GO:0097191
GO:0097300
GO:0097342
GO:0097343
GO:0097527
GO:1901026
GO:1903265
GO:1903800
GO:1905206
GO:1990000
GO:2000134
GO:2000377
GO:2001237
GO:2001238
GO:2001240
GT_A_87_P038086
Gga.5199.1.S1_at
Participates
as a component of
TNFAIP3:RIPK1 [cytosol] (Gallus gallus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Gallus gallus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Gallus gallus)
as a member of
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Gallus gallus)
as an input of
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Gallus gallus)
Other forms of this molecule
RIPK1 [cytosol]
RIPK1 [cytosol]
RIPK1 [cytosol]
RIPK1 [cytosol]
Inferred From
RIPK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_015131304.1
,
XP_015131305.1
OpenTargets
ENSG00000137275
Ensembl
ENSGALT00000037211
,
ENSGALP00000036418
,
ENSGALG00000012827
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