Reactome | ANAPC1 [nucleoplasm]

ANAPC1 [nucleoplasm]

Stable Identifier

R-GGA-174217

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

nucleoplasm

Synonyms

ANAPC1, A0A3Q2TZ07

Locations in the PathwayBrowser

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Cell Cycle (Gallus gallus)

- Cell Cycle, Mitotic (Gallus gallus)
  - Regulation of mitotic cell cycle (Gallus gallus)
    - APC/C-mediated degradation of cell cycle proteins (Gallus gallus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Gallus gallus)
        
        APC/C:Cdh1 polyubiquitinates SKP2 (Gallus gallus)
        
        PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC1 [nucleoplasm] (Gallus gallus)
        
        RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC1 [nucleoplasm] (Gallus gallus)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Gallus gallus)
        
        Phosphorylation of the APC/C (Gallus gallus)
        
        Free APC/C phosphorylated by Plk1 (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC1 [nucleoplasm] (Gallus gallus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Gallus gallus)
        
        Multiubiquitination of APC/C-associated Cdh1 (Gallus gallus)
        
        multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Gallus gallus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC1 [nucleoplasm] (Gallus gallus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC1 [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC1 [nucleoplasm] (Gallus gallus)
      - Regulation of APC/C activators between G1/S and early anaphase (Gallus gallus)
        
        Association of Cyclin A:Cdk2 with Cdh1 (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC1 [nucleoplasm] (Gallus gallus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC1 [nucleoplasm] (Gallus gallus)
        
        Dissociation of phospho-Cdh1 from the APC/C complex (Gallus gallus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC1 [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC1 [nucleoplasm] (Gallus gallus)
        
        Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Gallus gallus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC1 [nucleoplasm] (Gallus gallus)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC1 [nucleoplasm] (Gallus gallus)

Cellular responses to stimuli (Gallus gallus)

- Cellular responses to stress (Gallus gallus)
  - Cellular Senescence (Gallus gallus)
    - Senescence-Associated Secretory Phenotype (SASP) (Gallus gallus)
      - CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC1 [nucleoplasm] (Gallus gallus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC1 [nucleoplasm] (Gallus gallus)
      - CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Gallus gallus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC1 [nucleoplasm] (Gallus gallus)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC1 [nucleoplasm] (Gallus gallus)
      - Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Gallus gallus)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC1 [nucleoplasm] (Gallus gallus)
        
        Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC1 [nucleoplasm] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A3Q2TZ07

Gene Names

ANAPC1

Reference Genes

BioGPS Gene:421228 ANAPC1

ENSEMBL:ENSGALG00000008254

Monarch:421228 ANAPC1

NCBI Gene:421228 ANAPC1

Reference Transcript

RefSeq:XM_419303.5 ANAPC1

Other Identifiers

421228

GO:0005575

GO:0005622

GO:0005634

GO:0005680

GO:0006464

GO:0008150

GO:0032991

GO:0043226

GO:0070979

GT_A_87_P034574

GT_A_87_P127938

GT_A_87_P219173

GgaAffx.21038.1.S1_at

GgaAffx.21038.1.S1_s_at

GgaAffx.5210.1.S1_at

Participates

as a component of

phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)

Other forms of this molecule

ANAPC1 [cytosol]

Inferred From

ANAPC1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_419303.3

OpenTargets

ENSG00000153107

Ensembl

ENSGALT00000097399, ENSGALP00000067663, ENSGALG00000008254

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