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PIK3CA:PIK3R1 [cytosol]
Stable Identifier
R-GGA-1806218
Type
Complex
Species
Gallus gallus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism (Gallus gallus)
Metabolism of lipids (Gallus gallus)
Phospholipid metabolism (Gallus gallus)
PI Metabolism (Gallus gallus)
Synthesis of PIPs at the plasma membrane (Gallus gallus)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Gallus gallus)
PIK3C(1) [cytosol] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Gallus gallus)
PIK3(2) [cytosol] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by EGFR (Gallus gallus)
GAB1 signalosome (Gallus gallus)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
Signaling by ERBB2 (Gallus gallus)
PI3K events in ERBB2 signaling (Gallus gallus)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Gallus gallus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Gallus gallus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
Signaling by ERBB4 (Gallus gallus)
PI3K events in ERBB4 signaling (Gallus gallus)
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Gallus gallus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Gallus gallus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
Signaling by MET (Gallus gallus)
MET activates PI3K/AKT signaling (Gallus gallus)
MET bound PI3K generates PIP3 (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
Phosphorylated GAB1 recruits PI3K to MET (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
PIK3CA:PIK3R1 [cytosol] (Gallus gallus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
PIK3CA [cytosol]
(Gallus gallus)
PIK3R1 [cytosol]
(Gallus gallus)
Participates
as a member of
PI3K alpha, gamma [cytosol] (Gallus gallus)
PIK3C(1) [cytosol] (Gallus gallus)
PIK3(2) [cytosol] (Gallus gallus)
as an input of
Phosphorylated GAB1 recruits PI3K to MET (Gallus gallus)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Gallus gallus)
Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Gallus gallus)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Gallus gallus)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Gallus gallus)
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Gallus gallus)
as a component of
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Gallus gallus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Gallus gallus)
Inferred From
PIK3CA:PIK3R1 [cytosol]
(Homo sapiens)
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