Reactome | AP2A2(1-939) [cytosol]

AP2A2(1-939) [cytosol]

Stable Identifier

R-GGA-182155

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

A0A1D5NV94

Locations in the PathwayBrowser

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Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - Clathrin-mediated endocytosis (Gallus gallus)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Gallus gallus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        Clathrin-coated vesicle [cytosol] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        Clathrin-coated vesicle [cytosol] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
    - BAR domain proteins recruit dynamin (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Gallus gallus)
      - CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
    - Cargo recognition for clathrin-mediated endocytosis (Gallus gallus)
      - AP-2 directly binds some endocytic cargo (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        AP2:chlorpromazine [cytosol] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
      - AP2 binds chlorpromazine (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        AP2:chlorpromazine [cytosol] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
    - Clathrin recruits PIK3C2A (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        Clathrin-coated vesicle [cytosol] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        Clathrin-coated vesicle [cytosol] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        Clathrin-coated vesicle [cytosol] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        Clathrin-coated vesicle [cytosol] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        Clathrin-coated vesicle [cytosol] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
    - Initial binding of AP-2 and clathrin to PI(4,5)P2 (Gallus gallus)
      - AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
    - RAB5 and GAPVD1 bind AP-2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        Clathrin-coated vesicle [cytosol] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
    - SNX9 recruits components of the actin polymerizing machinery (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        AP-2:cargo [plasma membrane] (Gallus gallus)
        
        AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)
        
        p-T156 AP-2 Complex [cytosol] (Gallus gallus)
        
        AP2A2(1-939) [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A1D5NV94

Reference Genes

ENSEMBL:ENSGALG00000006799

ENSEMBL:ENSGALG00010024250.1

Reference Transcript

RefSeq:XM_015286613.1

Other Identifiers

423102

GO:0005886

GO:0005905

GO:0006886

GO:0006897

GO:0015031

GO:0016020

GO:0016192

GO:0019900

GO:0019901

GO:0019904

GO:0030117

GO:0030122

GO:0030131

GO:0031410

GO:0035615

GO:0043226

GO:0060090

GO:0072583

GO:0097718

GT_A_87_P018682

GT_A_87_P269883

GT_Sp_Chicken_CN233282_5401

Gga.13041.1.S1_at

Participates

as a component of

Other forms of this molecule

AP2A2(1-939) [endolysosome membrane]

AP2A2(1-939) [ficolin-1-rich granule membrane]

AP2A2(1-939) [secretory granule membrane]

AP2A2-3 [endocytic vesicle membrane]

AP2A2(1-939) [plasma membrane]

Inferred From

Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)

AP2A2(1-939) [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_015142099.1

Ensembl

ENSGALT00010059180, ENSGALP00010036119, ENSGALG00010024250

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