Reactome | EPS15 [cytosol]

EPS15 [cytosol]

Stable Identifier

R-GGA-182920

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

EPS15, A0A8V0ZYI9

Locations in the PathwayBrowser

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Cell-Cell communication (Gallus gallus)

- Cell junction organization (Gallus gallus)
  - Cell-cell junction organization (Gallus gallus)
    - Adherens junctions interactions (Gallus gallus)
      - Regulation of Homotypic Cell-Cell Adhesion (Gallus gallus)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Gallus gallus)
        
        Regulation of CDH1 Expression and Function (Gallus gallus)
        
        Regulation of CDH1 Function (Gallus gallus)
        
        Degradation of CDH1 (Gallus gallus)
        
        The complex of MDM2 and CDH1 translocates to early endosomes (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Signaling by Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by EGFR (Gallus gallus)
    - EGFR downregulation (Gallus gallus)
      - CBL-mediated ubiquitination of CIN85 (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Gallus gallus)
        
        EPS15:HGS:STAM [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Gallus gallus)
        
        EPS15:HGS:STAM [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
      - EGFR phosphorylates EPS15 (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Gallus gallus)
        
        EPS15:HGS:STAM [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
      - PTPN3 dephosphorylates EPS15 (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Gallus gallus)
        
        EPS15:HGS:STAM [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
      - Sprouty sequesters CBL away from active EGFR (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Gallus gallus)
        
        EPS15:HGS:STAM [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Gallus gallus)
        
        EPS15:HGS:STAM [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
  - Signaling by MET (Gallus gallus)
    - Negative regulation of MET activity (Gallus gallus)
      - EPS15 and HGS bind ubiquitinated MET (Gallus gallus)
        
        EPS15:HGS:STAM [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Gallus gallus)
        
        EPS15:HGS:STAM [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)

Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - Clathrin-mediated endocytosis (Gallus gallus)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Gallus gallus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Gallus gallus)
      - CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
    - Cargo recognition for clathrin-mediated endocytosis (Gallus gallus)
      - ARBB recruits GPCRs into clathrin-coated pits (Gallus gallus)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        UBQLN2:UIM-containing proteins [cytosol] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
      - Epsin family proteins bind ubiquitinated cargo (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
      - UBQLNs bind UIM-containing adaptor proteins (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        UNQLNs:UIM proteins [cytosol] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
    - Clathrin recruits PIK3C2A (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
    - RAB5 and GAPVD1 bind AP-2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
    - Recruitment of AP-2 complex and clathrin (Gallus gallus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
    - SNX9 recruits components of the actin polymerizing machinery (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)
        
        EPS15 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V0ZYI9

Gene Names

EPS15

Reference Genes

BioGPS Gene:424633 EPS15

ENSEMBL:ENSGALG00010024596.1

Monarch:424633 EPS15

NCBI Gene:424633 EPS15

UCSC:A0A8V0ZYI9 EPS15

Reference Transcript

Other Identifiers

424633

GO:0005509

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0005905

GO:0006895

GO:0006897

GO:0016020

GO:0016192

GO:0016197

GO:0016235

GO:0019065

GO:0030122

GO:0030132

GO:0030136

GO:0030674

GO:0031410

GO:0031593

GO:0032880

GO:0042802

GO:0043130

GO:0046718

GO:0046872

GO:0048268

GO:0060090

GO:0060170

GO:0065003

GO:0070086

GT_A_87_P037189

GT_A_87_P079406

GT_A_87_P127233

GT_Xhyb_Chicken_CN233505_3470

GT_Xhyb_Chicken_CN234059_3600

Gga.4092.1.S1_at

GgaAffx.11399.1.S1_at

GgaAffx.11399.1.S1_s_at

GgaAffx.6665.1.S1_s_at

Participates

as a component of

as a member of

EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)

This entity regulates

Positively

The complex of MDM2 and CDH1 translocates to early endosomes (Gallus gallus)

Other forms of this molecule

phospho-EPS15 [cytosol]

Inferred From

EPS15 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_015146503.2, XP_046778772.1

ENSEMBL

ENSGALT00010060009, ENSGALG00010024596, ENSGALP00010036769

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