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HGS [cytosol]
Stable Identifier
R-GGA-182954
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
HGS, A0A8V1ALR8
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Deubiquitination (Gallus gallus)
Ub-specific processing proteases (Gallus gallus)
USP8 deubiquitinates STAM2:HGS (Gallus gallus)
USP8:STAM2:HGS [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
USP8:Ub-STAM2:HGS [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by EGFR (Gallus gallus)
EGFR downregulation (Gallus gallus)
CBL-mediated ubiquitination of CIN85 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Gallus gallus)
EPS15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Gallus gallus)
EPS15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
EGFR phosphorylates EPS15 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Gallus gallus)
EPS15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
PTPN3 dephosphorylates EPS15 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Gallus gallus)
EPS15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
Sprouty sequesters CBL away from active EGFR (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Gallus gallus)
EPS15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Gallus gallus)
EPS15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
Signaling by MET (Gallus gallus)
Negative regulation of MET activity (Gallus gallus)
EPS15 and HGS bind ubiquitinated MET (Gallus gallus)
EPS15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Gallus gallus)
EPS15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
RHOBTB3 ATPase cycle (Gallus gallus)
RHOBTB3 binds interacting proteins at trans-Golgi network (Gallus gallus)
RHOBTB3 interacting proteins [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
RHOBTB3:ATP:RHOBTB3 interacting proteins [trans-Golgi network membrane] (Gallus gallus)
RHOBTB3 interacting proteins [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
Signaling by Rho GTPases (Gallus gallus)
RHO GTPase cycle (Gallus gallus)
RHOU GTPase cycle (Gallus gallus)
RHOU binds effectors at the plasma membrane (Gallus gallus)
RHOU effectors [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
RHOU:GTP:RHOU effectors [plasma membrane] (Gallus gallus)
RHOU effectors [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
Vesicle-mediated transport (Gallus gallus)
Membrane Trafficking (Gallus gallus)
Clathrin-mediated endocytosis (Gallus gallus)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Gallus gallus)
CLASP proteins:cargo [plasma membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
ubiquitinated cargo [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
CLASP proteins:cargo [plasma membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
ubiquitinated cargo [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
Cargo recognition for clathrin-mediated endocytosis (Gallus gallus)
Epsin family proteins bind ubiquitinated cargo (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
ubiquitinated cargo [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
ubiquitinated cargo [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
Clathrin recruits PIK3C2A (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
CLASP proteins:cargo [plasma membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
ubiquitinated cargo [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
CLASP proteins:cargo [plasma membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
ubiquitinated cargo [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
CLASP proteins:cargo [plasma membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
ubiquitinated cargo [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Gallus gallus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
CLASP proteins:cargo [plasma membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
ubiquitinated cargo [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
Endophilins recruit synaptojanins to the clathrin-coated pit (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
CLASP proteins:cargo [plasma membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
ubiquitinated cargo [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
CLASP proteins:cargo [plasma membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
ubiquitinated cargo [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
RAB5 and GAPVD1 bind AP-2 (Gallus gallus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
SNX9 recruits components of the actin polymerizing machinery (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
CLASP proteins:cargo [plasma membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
ubiquitinated cargo [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
CLASP proteins:cargo [plasma membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
ubiquitinated cargo [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
CLASP proteins:cargo [plasma membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
ubiquitinated cargo [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
CLASP proteins:cargo [plasma membrane] (Gallus gallus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
ubiquitinated cargo [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
HGS [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A8V1ALR8
Gene Names
HGS
Reference Genes
ENSEMBL:ENSGALG00010029348.1
UCSC:A0A8V1ALR8 HGS
Other Identifiers
428675
GO:0005737
GO:0005764
GO:0005768
GO:0005769
GO:0005829
GO:0006622
GO:0006886
GO:0008270
GO:0010324
GO:0010628
GO:0010642
GO:0016192
GO:0016525
GO:0019904
GO:0030948
GO:0031623
GO:0031901
GO:0032456
GO:0032585
GO:0033565
GO:0035091
GO:0043130
GO:0044389
GO:0046426
GO:0046872
GO:0061024
GO:0072657
GO:1903543
GT_A_87_P023077
GT_A_87_P067741
GT_A_87_P258213
GT_Sp_Chicken_BG641967_417
GT_Sp_Chicken_CN233766_5651
Gga.7570.1.S1_at
Participates
as a component of
ESCRT-0 [cytosol] (Gallus gallus)
USP8:STAM2:HGS [cytosol] (Gallus gallus)
USP8:Ub-STAM2:HGS [cytosol] (Gallus gallus)
p-Eps15:HGS:STAM [cytosol] (Gallus gallus)
EPS15:HGS:STAM [cytosol] (Gallus gallus)
as a candidate of
RHOU effectors [cytosol] (Gallus gallus)
as a member of
RHOBTB3 interacting proteins [cytosol] (Gallus gallus)
Inferred From
HGS [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSGALP00010043667
,
ENSGALT00010070976
,
ENSGALG00010029348
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