Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PDGF-A (L) [extracellular region]
Stable Identifier
R-GGA-184199
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
extracellular region
Synonyms
PDGFA-1, Q90WK2
Locations in the PathwayBrowser
Expand all
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Response to elevated platelet cytosolic Ca2+ (Gallus gallus)
Platelet degranulation (Gallus gallus)
Exocytosis of platelet alpha granule contents (Gallus gallus)
Platelet alpha granule contents [extracellular region] (Gallus gallus)
PDGF dimer [extracellular region] (Gallus gallus)
PDGF AB heterodimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
RAS GEFs [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by PDGF (Gallus gallus)
Autophosphorylation of PDGF alpha receptors (Gallus gallus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Gallus gallus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
Phospho PDGF alpha receptor:PDGF dimers [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
Downstream signal transduction (Gallus gallus)
Activated PLC gamma dissociates from the PDGF receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
Activation of Src (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
Crk binds to the active PDGF receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
GRB2:SOS1 complex binds to the active receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
Nck binds to the active PDGF receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PI3-kinase binds to the active receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PLC-gamma binds to the active receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
Phosphorylation of PLCgamma by PDGFR (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
SH2 domain of Src binds to the active receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
SHP2 binds to the active receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
STAT binds to the active receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
p130Cas and C3G bind PDGFR bound Crk (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGF binds to extracellular matrix proteins (Gallus gallus)
PDGF A and B chains with retention motif [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGF A and B chains:ECM complex [extracellular region] (Gallus gallus)
PDGF A and B chains with retention motif [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGF dimer binds two receptors simultaneously (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGF:PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGF-AA clevage by Furin (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGFRs bind type I TKI (Gallus gallus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Gallus gallus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-A (L) [extracellular region] (Gallus gallus)
External Reference Information
External Reference
UniProt:Q90WK2
Gene Names
PDGF-A (L)
Reference Genes
ENSEMBL:ENSGALG00000003642
ENSEMBL:ENSGALG00010022164.1 PDGF-A (L)
Other Identifiers
374196
GO:0005161
GO:0005576
GO:0005615
GO:0008083
GO:0008284
GO:0016020
GO:0023052
GO:0030335
GO:0031954
GO:0036211
GO:0048008
GO:0048018
GO:0048870
GO:0051897
GO:0070374
GO:0098772
Gga.3899.1.S1_a_at
Gga.3899.3.S1_a_at
Participates
as a component of
PDGF AB heterodimer [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
as a member of
PDGF A and B chains with retention motif [extracellular region] (Gallus gallus)
Other forms of this molecule
PDGF-A (L) [platelet alpha granule lumen]
PDGF-A (L) [endoplasmic reticulum lumen]
PDGF-A (L) [endoplasmic reticulum lumen]
PDGF-A (L) [Golgi lumen]
PDGF-A (L) [Golgi membrane]
PDGF-A (L) [Golgi membrane]
PDGF-A (L) [extracellular region]
Inferred From
Active platelet-derived growth factor A chain isoforms [extracellular region]
(Homo sapiens)
PDGFA-1 [extracellular region]
(Homo sapiens)
Cross References
Ensembl
ENSGALT00010053929
,
ENSGALP00010032478
,
ENSGALG00010022164
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
