ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate

Stable Identifier
R-GGA-187586
Type
Reaction [transition]
Species
Gallus gallus
Compartment
cytosol
ReviewStatus
5/5
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ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate
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Cytosolic argininosuccinate synthetase (ASS1) catalyzes the reaction of ATP, aspartate, and citrulline to form argininosuccinate, AMP, and pyrophosphate. The enzyme has been partially purified from kidney tissue (it was undetectable in liver) and biochemically characterized. The ASS1 gene has not been directly studied but rather has been identified computationally in the ENSEMBL chicken gene set as an open reading frame capable of encoding a protein similar to human ASS1.
Literature References
PubMed ID Title Journal Year
14064979 Enzymes of arginine metabolism in chicks

Ratner, S, Tamir, H

Arch Biochem Biophys 1963
14061730 A study of ornithine, citrulline and arginine synthesis in growing chicks

Ratner, S, Tamir, H

Arch Biochem Biophys 1963
Participants
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Output
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as an event of
Catalyst Activity

argininosuccinate synthase activity of ASS1 [cytosol]

Physical Entity
ASS1 [cytosol] (Gallus gallus)
Activity
argininosuccinate synthase activity (GO:0004055)
Authored
Schmidt, C  (2006-09-20)
Reviewed
D'Eustachio, P  (2008-09-10)
Created
Schmidt, C  (2006-09-20)
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