Reactome | SRC-2 [cytosol]

SRC-2 [cytosol]

Stable Identifier

R-GGA-191648

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

P00523

Locations in the PathwayBrowser

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Developmental Biology (Gallus gallus)

- Nervous system development (Gallus gallus)
  - Axon guidance (Gallus gallus)
    - EPH-Ephrin signaling (Gallus gallus)
      - EPH-ephrin mediated repulsion of cells (Gallus gallus)
        
        EPHA binds TIAM1 (Gallus gallus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Gallus gallus)
        
        SRC,FYN,YES,LYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Gallus gallus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Gallus gallus)
        
        SRC,FYN,YES,LYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        SFKs phosphorylate VAV2,3 (Gallus gallus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Gallus gallus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN,YES,LYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Gallus gallus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN,YES,LYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        SRC,FYN,YES,LYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Gallus gallus)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Gallus gallus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Gallus gallus)
        
        SRC,FYN,YES,LYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Gallus gallus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Gallus gallus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN,YES,LYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        p-EPHs bind VAV2,3 (Gallus gallus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Gallus gallus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN,YES,LYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN,YES,LYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - EPHA-mediated growth cone collapse (Gallus gallus)
        
        NGEF exchanges GTP for GDP on RHOA (Gallus gallus)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Gallus gallus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Gallus gallus)
        
        SRC,FYN,YES,LYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - EPHB-mediated forward signaling (Gallus gallus)
        
        EPHB phosphorylates TIAM1 (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Gallus gallus)
        
        SRC,FYN,YES,LYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Gallus gallus)
        
        SRC,FYN,YES,LYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        EPHB:NMDAR binds TIAM1 (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Gallus gallus)
        
        SRC,FYN,YES,LYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Gallus gallus)
        
        SRC,FYN,YES,LYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Gallus gallus)
        
        SRC,FYN,YES,LYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - Ephrin signaling (Gallus gallus)
        
        EFNB:GRB4 binds GIT1 (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        EFNBs bind SFKs (Gallus gallus)
        
        EPHBs:EFNBs:SRC,FYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        SRC,FYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        GIT1 binds bPIX (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        PAK binds RAC and bPIX (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        PAKs autophosphorylate (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        PAKs phosphorylate MLC (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        bPIX exchanges GTP for GDP on RAC, activating it (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        p-EFNB binds GRB4 (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Gallus gallus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Gallus gallus)
        
        SRC,FYN [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
    - L1CAM interactions (Gallus gallus)
      - Recycling pathway of L1 (Gallus gallus)
        
        Phosphorylation of L1 by SRC (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
    - RET signaling (Gallus gallus)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Gallus gallus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:SRC-1,RAP1GAP [plasma membrane] (Gallus gallus)
        
        SRC-1, RAP1GAP [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        SRC-1, RAP1GAP [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Integrin signaling (Gallus gallus)
  - Autophosphorylation of SRC (Gallus gallus)
    - SRC-2 [cytosol] (Gallus gallus)
  - p130Cas linkage to MAPK signaling for integrins (Gallus gallus)
    - Phosphorylation of BCAR1 by SRC-PTK2 complex (Gallus gallus)
      - FAK-SRC complex [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
- Signaling by Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by SCF-KIT (Gallus gallus)
    - Dimerization of STATs (Gallus gallus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
    - Disassociation and translocation of STATs to the nucleus (Gallus gallus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Gallus gallus)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
    - Indirect recruitment of GAB2 to p-KIT (Gallus gallus)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Gallus gallus)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
    - JAK2 binds to p-KIT (Gallus gallus)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
    - Phosphorylation of GAB2 by SFKs (Gallus gallus)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
    - Phosphorylation of JAK2 (Gallus gallus)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
    - Phosphorylation of SHP2 by SFKs (Gallus gallus)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
    - Phosphorylation of STATs (Gallus gallus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Gallus gallus)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
    - Recruitment of STATs (Gallus gallus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
    - Regulation of KIT signaling (Gallus gallus)
      - Phosphorylation of APS (Gallus gallus)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - Recruitment of CBL to KIT (Gallus gallus)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Gallus gallus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Gallus gallus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Gallus gallus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
    - SHP2 interacts with p-KIT (Gallus gallus)
      - SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
    - Synthesis of PIP3 from PIP2 by PI3K (Gallus gallus)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
        
        SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
  - Signaling by VEGF (Gallus gallus)
    - VEGFA-VEGFR2 Pathway (Gallus gallus)
      - Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - CRK binds BCAR1 and or PXN (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - DOCK180:ELMO binds CRK (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - HSP90AA1 binds p-6Y-VEGFR2 (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - PXN binds p-6Y,S732-PTK2 (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - Phosphorylation of SRC-1 (Gallus gallus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - SRC-1 binds p-Y397-PTK2 (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - SRC-1 phosphorylates PTK2-beta (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - SRC-1 phosphorylates SHB (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - SRC-1 phosphorylates p-Y397-PTK2 (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - Src kinases phosphorylate VAV (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - VEGFR2 mediated cell proliferation (Gallus gallus)
        
        SFKs phosphorylate PLCG1 (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
      - p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        SRC-2 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:P00523 SRC

Gene Names

SRC

Chain

initiator methionine:1, chain:2-533

Reference Genes

BioGPS Gene:396442 SRC

ENSEMBL:ENSGALG00000003855 SRC

KEGG Gene (Gallus gallus):396442 SRC

Monarch:396442 SRC

NCBI Gene:396442 SRC

Reference Transcript

Participates

as a component of

as an input of

as a member of

Other forms of this molecule

SRC [cytosol]

phospho-p-Y416-SRC [cytosol]

Src [cytosol]

MyrG-SRC [plasma membrane]

SRC-1 [plasma membrane]

phospho-p-Y419-SRC [cytosol]

phospho-MyrG,p-Y530-SRC [plasma membrane]

phospho-MyrG-p-Y419-SRC [plasma membrane]

Inferred From

Activated SRC-1 [cytosol] (Homo sapiens)

SRC-2 [cytosol] (Homo sapiens)

SRC-1 [cytosol] (Homo sapiens)

Cross References

ZINC - Investigational

SRC_CHICK

RefSeq

NP_990788.2, XP_015151834.1

ZINC - World Drugs

SRC_CHICK

OpenTargets

ENSG00000197122

ZINC - FDA approved

SRC_CHICK

ZINC - Substances

SRC_CHICK

ZINC target

P00523

PRO

P00523

ZINC - Predictions - Purchasable

SRC_CHICK

PDB

6XVO, 7A33, 3FJ5, 3LOK, 6XVM, 4DGG, 7NES, 5TEH, 4LE9, 3SVV, 5J5S, 2OIQ, 5T0P, 3G6G, 3U4W, 3EN4, 7A3D, 4HVW, 7D57, 7A3B, 5SWH, 4MCV, 6HVE, 3OEZ, 4OMP, 3F3W, 4OMO, 1RLP, 1SRL, 3TZ7, 3UQF, 4OMN, 3OF0, 3EL7, 3F3T, 4OMM, 7A39, 1NLP, 5D12, 5ECA, 4LGH, 7WF5, 5D10, 4RTW, 7A34, 5BMM, 5XP5, 3D7T, 7A31, 2QQ7, 5OB2, 3DQW, 3EN6, 3QLF, 5OB0, 1P13, 5K9I, 3G6H, 6XX4, 3EL8, 5SYS, 6XX2, 4OMQ, 3TZ8, 3UQG, 4QT7, 4YBK, 3U51, 4YBJ, 1RLQ, 3F3U, 7A37, 4RTX, 1PRL, 7A35, 6XVN, 4JZ3, 7NET, 3EN7, 7D5O, 7NER, 4FIC, 3QLG, 2QI8, 7A3E, 2QLQ, 7AH3, 6HVF, 7A3C, 1SRM, 4HVU, 7A3A, 3GEQ, 3G5D, 2PTK, 3F3V, 7A38, 5D11, 6L8L, 1F1W, 4RTY, 5XP7, 1PRM, 3DQX, 4U5J, 5EC7, 4AGW, 4RTU, 7A32, 4JZ4, 7A30, 5OB1, 5OAV, 3F6X, 6WIW, 6XX5, 6XX3, 3EN5, 2HWP, 3TZ9, 4HVV, 1F2F, 2HWO, 5I11, 1NLO, 4O2P, 4RTZ, 3D7U, 4OML, 4LGG, 7A36, 4RTV

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41240 CSK	2	CSK [plasma membrane] (R-HSA-180499) CSK [cytosol] (R-HSA-203776)	0.719	7
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.59	4
UniProt:Q00944	11	phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-GGA-8874613) phospho-p-Y194,Y397-PTK2 [cytosol] (R-GGA-8874600) phospho-pY-PTK2 [cytosol] (R-GGA-9632393) phospho-p-5Y-PTK2 [cytosol] (R-GGA-5218711) phospho-p-5Y,S732-PTK2 [cytosol] (R-GGA-5229006) phospho-p-6Y,S732-PTK2 [cytosol] (R-GGA-5218694) PTK2(773-1052) [cytosol] (R-GGA-202829) PTK2(1-772) [cytosol] (R-GGA-202827) PTK2 [cytosol] (R-GGA-201621) phospho-p-Y397-PTK2 [cytosol] (R-GGA-354068) phospho-p-6Y-PTK2 [cytosol] (R-GGA-354128)	0.589	3
UniProt:O88703	1	HCN2 [plasma membrane] (R-MMU-977502)	0.581	5
UniProt:Q9QWY8-1 ASAP1			0.581	3
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.564	2
UniProt:Q90738 AFAP1			0.564	3
UniProt:Q9Y4D1 DAAM1	1	DAAM1 [cytosol] (R-HSA-351052)	0.556	3
UniProt:P61980	2	Hnrnpk [nucleoplasm] (R-RNO-4570532) Hnrnpk [nucleoplasm] (R-RNO-71945)	0.544	2
UniProt:Q9QWY8-2 ASAP1			0.544	2
UniProt:P18052	1	PTPRA [plasma membrane] (R-MMU-388755)	0.525	2

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