Reactome | PRKAG2 [cytosol]

PRKAG2 [cytosol]

Stable Identifier

R-GGA-200419

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

PRKAG2, F1NXL4

Locations in the PathwayBrowser

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Autophagy (Gallus gallus)

- Macroautophagy (Gallus gallus)
  - AMPK (complex) phosphorylates ULK1 (complex) (Gallus gallus)
    - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG2 [cytosol] (Gallus gallus)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG2 [cytosol] (Gallus gallus)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG2 [cytosol] (Gallus gallus)
  - Thr-180 of ULK1 is phosphorylated (Gallus gallus)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG2 [cytosol] (Gallus gallus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG2 [cytosol] (Gallus gallus)
  - ULK complex translocates to the ER (Gallus gallus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG2 [cytosol] (Gallus gallus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG2 [cytosol] (Gallus gallus)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Gallus gallus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG2 [cytosol] (Gallus gallus)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Gallus gallus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG2 [cytosol] (Gallus gallus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG2 [cytosol] (Gallus gallus)
  - ULK1 phosphorylates Beclin-1 (Gallus gallus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG2 [cytosol] (Gallus gallus)
  - p-AMPK:AMP binds the ULK complex (Gallus gallus)
    - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG2 [cytosol] (Gallus gallus)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG2 [cytosol] (Gallus gallus)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Gallus gallus)
    - p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
      - p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG2 [cytosol] (Gallus gallus)

Gene expression (Transcription) (Gallus gallus)

- RNA Polymerase II Transcription (Gallus gallus)
  - Generic Transcription Pathway (Gallus gallus)
    - Transcriptional Regulation by TP53 (Gallus gallus)
      - TP53 Regulates Metabolic Genes (Gallus gallus)
        
        SESN1,2,3 bind AMPK (Gallus gallus)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG2 [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Gallus gallus)
        
        p-AMPK heterotrimer [cytosol] (Gallus gallus)
        
        AMPK gamma [cytosol] (Gallus gallus)
        
        PRKAG2 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:F1NXL4

Gene Names

PRKAG2

Reference Genes

BioGPS Gene:420435 PRKAG2

ENSEMBL:ENSGALG00000006219

ENSEMBL:ENSGALG00010027135.1 PRKAG2

Monarch:420435 PRKAG2

NCBI Gene:420435 PRKAG2

Reference Transcript

RefSeq:NM_001278142.1 PRKAG2

Other Identifiers

420435

GO:0005634

GO:0005737

GO:0016208

GO:0019887

GO:0019901

GO:0031588

GO:0043226

GO:0098772

GT_A_87_P009681

GT_A_87_P188598

Gga.4517.1.S1_at

GgaAffx.12380.1.S1_s_at

Participates

as a member of

AMPK gamma [cytosol] (Gallus gallus)

Other forms of this molecule

PRKAG2 [nucleoplasm]

Inferred From

PRKAG2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001265071.1

OpenTargets

ENSG00000106617

Ensembl

ENSGALG00010027135, ENSGALT00010065799, ENSGALP00010040065

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