Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PTN [extracellular region]
Stable Identifier
R-GGA-201500
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
extracellular region
Synonyms
PTN, P32760
Locations in the PathwayBrowser
Expand all
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ALK (Gallus gallus)
ALK autophosphorylation (Gallus gallus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Gallus gallus)
ligand-bound ALK dimer [plasma membrane] (Gallus gallus)
PTN:ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
ligand-bound ALK dimer [plasma membrane] (Gallus gallus)
PTN:ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
Active ALK binds PLCG1 (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
Active ALK:PLCG1 [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
Active ALK binds SHC1 (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
Active ALK:SHC1 [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
Active ALK dimer binds IRS1 (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
Active ALK:IRS1 [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
Active ALK phosphorylates IRS1 (Gallus gallus)
Active ALK:IRS1 [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
Active ALK:pY-IRS1 [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
Active ALK phosphorylates PLCG1 (Gallus gallus)
Active ALK:PLCG1 [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
Active ALK:p-4Y PLCG1 [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
Active ALK phosphorylates SHC1 (Gallus gallus)
Active ALK:SHC1 [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
Active ALK:p-3Y SHC1 [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
Active ALK recruits PI3K (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
Active ALK:PI3K [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
Liganded-ALK dimer binds type I ALK-binding TKIs (Gallus gallus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Gallus gallus)
ligand-bound ALK dimer [plasma membrane] (Gallus gallus)
PTN:ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
ligand-bound ALK dimer [plasma membrane] (Gallus gallus)
PTN:ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
MDK and PTN in ALK signaling (Gallus gallus)
(PTN,MDK):PTPRZ oligomerizes (Gallus gallus)
(PTN,MDK):PTPRZ [plasma membrane] (Gallus gallus)
PTN,MDK [extracellular region] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Gallus gallus)
(PTN,MDK):PTPRZ [plasma membrane] (Gallus gallus)
PTN,MDK [extracellular region] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
ALK binds ligand pleiotrophin (PTN) (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
PTN:ALK [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
PTN and MDK bind to PTPRZ (Gallus gallus)
(PTN,MDK):PTPRZ [plasma membrane] (Gallus gallus)
PTN,MDK [extracellular region] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
PTN,MDK [extracellular region] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Gallus gallus)
(PTN,MDK):ALK dimer [plasma membrane] (Gallus gallus)
PTN:ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Gallus gallus)
(PTN,MDK):PTPRZ [plasma membrane] (Gallus gallus)
PTN,MDK [extracellular region] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
(PTN,MDK):p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
PI3K synthesizes PIP3 downstream of ALK (Gallus gallus)
Active ALK:PI3K [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
STAT3 is phosphorylated downstream of active ALK (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN [extracellular region] (Gallus gallus)
External Reference Information
External Reference
UniProt:P32760
Gene Names
PTN
Reference Genes
BioGPS Gene:418125 PTN
ENSEMBL:ENSGALG00000040493
ENSEMBL:ENSGALG00010013828.1 PTN
ENSEMBL:ENSGALG00015020790 PTN
KEGG Gene (Gallus gallus):418125 PTN
Monarch:418125 PTN
NCBI Gene:418125 PTN
Reference Transcript
RefSeq:XM_015285608.1 PTN
RefSeq:XM_015285616.1 PTN
RefSeq:NM_001276362.1 PTN
Other Identifiers
418125
GO:0001503
GO:0001756
GO:0005576
GO:0005615
GO:0007165
GO:0007420
GO:0007507
GO:0007612
GO:0008083
GO:0008201
GO:0008284
GO:0010594
GO:0021915
GO:0023052
GO:0030282
GO:0035374
GO:0035989
GO:0043588
GO:0048018
GO:0048856
GO:0048870
GO:0050877
GO:0050896
GO:0051216
GO:0051781
GO:0060173
GO:0061054
GO:0061056
GO:0098772
GT_A_87_P007927
GT_A_87_P107708
GT_A_87_P231993
GT_Sp_Chicken_CN224781_4679
GT_Sp_Chicken_CO763386_8259
GT_Xhyb_Chicken_CN225520_3240
Gga.1479.1.S1_at
Gga.1479.2.S1_a_at
Gga.16474.1.S1_at
Participates
as a member of
PTN,MDK [extracellular region] (Gallus gallus)
as a component of
PTN:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
PTN:ALK [plasma membrane] (Gallus gallus)
PTN:ALK dimer [plasma membrane] (Gallus gallus)
as an input of
ALK binds ligand pleiotrophin (PTN) (Gallus gallus)
Inferred From
PTN [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_001263291.1
,
XP_015141102.1
,
XP_015141094.1
OpenTargets
ENSG00000105894
Ensembl
ENSGALT00010033199
,
ENSGALP00010019616
,
ENSGALG00010013828
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text