Vitronectin prevents C9 polymerization

Stable Identifier
R-GGA-2132088
Type
Reaction [binding]
Species
Gallus gallus
Compartment
extracellular region
ReviewStatus
5/5
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Vitronectin prevents C9 polymerization
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Vitronectin blocks MAC complex formation by inhibiting C9 polymerization.

Vitronectin transcripts were detected in the brain, liver and spleen of adult chickens. The polypeptide sequence of chicken vitronectin exhibits 57% identity with human ortholog. Chicken events involving vitronectin have not been verified experimentally but are inferred from properties of the orthologous human proteins.

Literature References
Participants
Input
Output
Participates
as an event of
Inferred From
Formation of soluble VTN:C5b-C9 (Homo sapiens)
Authored
Shamovsky, V  (2012-12-20)
Reviewed
D'Eustachio, P  (2012-11-07)
Jupe, S  (2013-01-31)
Created
Shamovsky, V  (2012-02-21)
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