Activation of C1r within the C1complement complex

Stable Identifier
R-GGA-2132122
Type
Reaction [omitted]
Species
Gallus gallus
Compartment
ReviewStatus
5/5
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Conformational changes in the C1 complex result in activation of C1r. The active form of C1r cleaves C1s to generate an active serine protease which, in turn, cleaves both complement C4 and C2.

This event was inferred from the curated human reaction.

Literature References
PubMed ID Title Journal Year
1249422 Activation of C1r by proteolytic cleavage

Cooper, NR, Ziccardi, RJ

J Immunol 1976
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of IgM:Antigen:C1q:pro-C1r:pro-C1s [plasma membrane]

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