Chicken factor B-like protease (factor B) was found to be equally related to mammalian complement components B and C2A (Kjalke M. et al. 1993). In addition, a homologue for C2 was not found in chickens and factor B seemed to participate in both classical and alternative pathways of complement activation (Barta O & Hubbert NL 1978; Kjalke M. et al. 1993). It was assumed that the role of C2 may be fulfilled by the chicken factor B-like protease, an evolutionary remnant of a common C2/factor B ancestor (Kjalke M. et al. 1993).
Marston, D, Sandrini, SM, Stover, CM, Schwaeble, WJ, Presanis, JS, Khan, SU, Lynch, NJ
Barta, O, Hubbert, NL
Welinder, KG, Koch, C, Kjalke, M
Yang, K, Lambris, JD, Hajishengallis, G, Ricklin, D
Nonaka, M, Goetz, W, Flajnik, MF, Ohta, Y, Hossain, MZ
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