Spatial and temporal expression profiles of chicken genes involved in membrane attack complex (MAC) formation showed that a wide range of adult chicken tissues express MAC regulatory genes - CD59, vitronectin (VTN) and clusterin (CLU), with the liver being the major source of their produced transcripts. MAC regulatory chicken genes are also expressed in all the developmental stages investigated [Mikrou A and Zarkadis IK 2010]. The chicken complement regulatory proteins remain to be structurally and functionally characterized so the chicken events annotated here are mostly inferred from the human complement cascade and should be considered as a suggestive model.
Hattori, T, Tamaki, Y, Yamada, N, Oshiumi, H, Mizuno, S, Goitsuka, R, Seya, T, Matsumoto, M, Ohba, S, Katoh, J, Shida, K, Kimura, Y, Inoue, N
Mikrou, A, Zarkadis, IK
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