Monoubiquitination of PCNA

Stable Identifier
R-GGA-216988
Type
Reaction [transition]
Species
Gallus gallus
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Monoubiquitination of PCNA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RAD18 catalyzes mono ubiquitination of PCNA by its RING zinc finger domain, a modification central to DNA damage bypass and post replication repair. In contrast to yeast, studies performed in chicken DT40 cells reveal that RAD18 is essential for both post replication repair as well as homologous recombination repair. Because the repair of stalled replication forks is channeled into these two pathways, RAD18 minimizes the toxic effects of non homologous end joining (NHEJ) repair pathways. Thus, vertebrate RAD18 regulates the balance between NHEJ and HR.
Literature References
PubMed ID Title Journal Year
16923963 Role for RAD18 in homologous recombination in DT40 cells

Yamazoe, M, Kabani, S, Simpson, LJ, Sale, JE, Sz?ts, D

Mol Cell Biol 2006
17242200 RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair

Lan, L, Hochegger, H, Saberi, A, Takeda, S, Yasui, A, Teraoka, H, Sale, JE, Murakawa, Y, Buerstedde, JM, Arakawa, H, Yokomori, K, Taniguchi, Y, Helleday, T, Zeng, W, Szuts, D

Mol Cell Biol 2007
12374756 RAD18 and RAD54 cooperatively contribute to maintenance of genomic stability in vertebrate cells

Takeda, S, Tateishi, S, Yamashita, YM, Matsusaka, T, Okada, T, Sonoda, E, Araki, K, Zhao, GY, Yamaizumi, M

EMBO J 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin-protein transferase activity of RAD18 [nucleoplasm]

Physical Entity
RAD18 [nucleoplasm] (Gallus gallus)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Authored
Saxena, A  (2008-01-04)
Reviewed
Borowiec, JA  (2009-04-24)
Created
Saxena, A  (2008-03-26)
Cite Us!