Reactome | DNAJC6 [cytosol]

DNAJC6 [cytosol]

Stable Identifier

R-GGA-264472

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

DNAJC6, A0A8V0ZQW8

Locations in the PathwayBrowser

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Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - Clathrin-mediated endocytosis (Gallus gallus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        GAK,DNAJC6 [cytosol] (Gallus gallus)
        
        DNAJC6 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        GAK,DNAJC6 [cytosol] (Gallus gallus)
        
        DNAJC6 [cytosol] (Gallus gallus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)
      - GAK,DNAJC6 [cytosol] (Gallus gallus)
        
        DNAJC6 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        GAK,DNAJC6 [cytosol] (Gallus gallus)
        
        DNAJC6 [cytosol] (Gallus gallus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        GAK,DNAJC6 [cytosol] (Gallus gallus)
        
        DNAJC6 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        GAK,DNAJC6 [cytosol] (Gallus gallus)
        
        DNAJC6 [cytosol] (Gallus gallus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        GAK,DNAJC6 [cytosol] (Gallus gallus)
        
        DNAJC6 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        GAK,DNAJC6 [cytosol] (Gallus gallus)
        
        DNAJC6 [cytosol] (Gallus gallus)
    - RAB5 and GAPVD1 bind AP-2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        GAK,DNAJC6 [cytosol] (Gallus gallus)
        
        DNAJC6 [cytosol] (Gallus gallus)
  - trans-Golgi Network Vesicle Budding (Gallus gallus)
    - Golgi Associated Vesicle Biogenesis (Gallus gallus)
      - trans-Golgi Network Derived Vesicle Uncoating (Gallus gallus)
        
        HSC70:Auxillin Complex [cytosol] (Gallus gallus)
        
        DNAJC6 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V0ZQW8

Gene Names

DNAJC6

Reference Genes

BioGPS Gene:424698 DNAJC6

ENSEMBL:ENSGALG00010024142.1

Monarch:424698 DNAJC6

NCBI Gene:424698 DNAJC6

UCSC:A0A8V0ZQW8 DNAJC6

Reference Transcript

RefSeq:XM_015291026.4 DNAJC6

Other Identifiers

424698

GO:0003824

GO:0004721

GO:0005737

GO:0014069

GO:0016191

GO:0016192

GO:0016311

GO:0016787

GO:0017124

GO:0030136

GO:0030276

GO:0031410

GO:0031982

GO:0036465

GO:0043226

GO:0045202

GO:0072318

GO:0072583

GO:0098894

GO:0140096

GO:1905443

GO:2000369

GT_A_87_P158793

GT_A_87_P272663

Gga.12145.1.S1_at

GgaAffx.23432.1.S1_s_at

GgaAffx.23432.3.S1_s_at

Participates

as a component of

HSC70:Auxillin Complex [cytosol] (Gallus gallus)

as a member of

GAK,DNAJC6 [cytosol] (Gallus gallus)

Inferred From

DNAJC6 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_015146512.2

ENSEMBL

ENSGALT00010058875, ENSGALG00010024142, ENSGALP00010035840

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