Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PAK2 dimer [cytosol]
Stable Identifier
R-GGA-2685645
Type
Complex
Species
Gallus gallus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Developmental Biology (Gallus gallus)
Nervous system development (Gallus gallus)
Axon guidance (Gallus gallus)
Semaphorin interactions (Gallus gallus)
Sema3A PAK dependent Axon repulsion (Gallus gallus)
Activation of PAK by Rac1 (Gallus gallus)
PAK1,2,3 dimer [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Regulation of T cell activation by CD28 family (Gallus gallus)
Co-stimulation by CD28 (Gallus gallus)
CD28 dependent Vav1 pathway (Gallus gallus)
Activation of PAKs by RAC1 and CDC42 (Gallus gallus)
PAK1,2,3 dimer [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
Innate Immune System (Gallus gallus)
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
FCERI mediated MAPK activation (Gallus gallus)
Autophosphorylation of PAK (Gallus gallus)
PAK dimer [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Gallus gallus)
PAK dimer [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
Recruitment of PAK to the membrane by binding active RAC1 (Gallus gallus)
PAK dimer [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Gallus gallus)
PAK dimer [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK6/MAPK4 signaling (Gallus gallus)
Activation of PAKs by RAC1 and CDC42 (Gallus gallus)
PAK1,2,3 dimer [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
CDC42:GTP binds PAK2 (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Gallus gallus)
PAK2 dimer:CDC42:GTP [plasma membrane] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
PAK2 autophorylates (Gallus gallus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Gallus gallus)
PAK2 dimer:CDC42:GTP [plasma membrane] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
PAK2 binds NCK (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
VEGFR2 mediated vascular permeability (Gallus gallus)
PAK1-3 autophosphorylates (Gallus gallus)
PAK1,2,3 dimer [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
PAK1-3 dimer disassociates (Gallus gallus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Gallus gallus)
PAK1,2,3 dimer [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
RAC1 binds PAK1-3 (Gallus gallus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Gallus gallus)
PAK1,2,3 dimer [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
PAK1,2,3 dimer [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
Signaling by Rho GTPases (Gallus gallus)
RHO GTPase Effectors (Gallus gallus)
RHO GTPases activate PAKs (Gallus gallus)
RAC1 and CDC42 activate PAK2 (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
RHO GTPase cycle (Gallus gallus)
RAC1 GTPase cycle (Gallus gallus)
RAC1 binds effectors at the plasma membrane (Gallus gallus)
RAC1 effectors [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
RAC1:GTP:RAC1 effectors [plasma membrane] (Gallus gallus)
RAC1 effectors [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
RAC2 GTPase cycle (Gallus gallus)
RAC2 binds effectors at the plasma membrane (Gallus gallus)
RAC2 plasma membrane effectors [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Gallus gallus)
RAC2 plasma membrane effectors [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
RAC3 GTPase cycle (Gallus gallus)
RAC3 binds effectors at the plasma membrane (Gallus gallus)
RAC3 effectors [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
RAC3:GTP:RAC3 effectors [plasma membrane] (Gallus gallus)
RAC3 effectors [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
RHOG GTPase cycle (Gallus gallus)
RHOG binds effectors at the plasma membrane (Gallus gallus)
RHOG plasma membrane effectors [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Gallus gallus)
RHOG plasma membrane effectors [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
RHOH GTPase cycle (Gallus gallus)
RHOH binds effectors at the plasma membrane (Gallus gallus)
RHOH effectors [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
RHOH:GTP:RHOH effectors [plasma membrane] (Gallus gallus)
RHOH effectors [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
RHOQ GTPase cycle (Gallus gallus)
RHOQ binds effectors at the plasma membrane (Gallus gallus)
RHOQ effectors [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
RHOQ:GTP:RHOQ effectors [plasma membrane] (Gallus gallus)
RHOQ effectors [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
RHOU GTPase cycle (Gallus gallus)
RHOU binds effectors at the plasma membrane (Gallus gallus)
RHOU effectors [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
RHOU:GTP:RHOU effectors [plasma membrane] (Gallus gallus)
RHOU effectors [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
RHOV GTPase cycle (Gallus gallus)
RHOV binds effectors at the plasma membrane (Gallus gallus)
RHOV effectors [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
RHOV:GTP:RHOV effectors [plasma membrane] (Gallus gallus)
RHOV effectors [cytosol] (Gallus gallus)
PAK2 dimer [cytosol] (Gallus gallus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
PAK2 [cytosol]
(Gallus gallus)
Participates
as a member of
RHOV effectors [cytosol] (Gallus gallus)
RHOH effectors [cytosol] (Gallus gallus)
CDC42 effectors [cytosol] (Gallus gallus)
RAC1 effectors [cytosol] (Gallus gallus)
RAC3 effectors [cytosol] (Gallus gallus)
PAK1,2,3 dimer [cytosol] (Gallus gallus)
PAK dimer [cytosol] (Gallus gallus)
as a candidate of
RHOQ effectors [cytosol] (Gallus gallus)
RAC2 plasma membrane effectors [cytosol] (Gallus gallus)
RHOG plasma membrane effectors [cytosol] (Gallus gallus)
RHOJ effectors [cytosol] (Gallus gallus)
RHOU effectors [cytosol] (Gallus gallus)
as an input of
PAK2 binds NCK (Gallus gallus)
RAC1 and CDC42 activate PAK2 (Gallus gallus)
as a component of
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Gallus gallus)
PAK2 dimer:CDC42:GTP [plasma membrane] (Gallus gallus)
Inferred From
PAK2 dimer [cytosol]
(Homo sapiens)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text