Reactome | TFAP2C [nucleoplasm]

TFAP2C [nucleoplasm]

Stable Identifier

R-GGA-3234071

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

nucleoplasm

Synonyms

monoSUMO1-K10-TFAP2C, E1C5K7

Locations in the PathwayBrowser

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Gene expression (Transcription) (Gallus gallus)

- RNA Polymerase II Transcription (Gallus gallus)
  - Generic Transcription Pathway (Gallus gallus)
    - Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Gallus gallus)
      - Negative regulation of activity of TFAP2 (AP-2) family transcription factors (Gallus gallus)
        
        SUMOylation of TFAP2C with SUMO1 (Gallus gallus)
        
        SUMO1:TFAP2C homodimer [nucleoplasm] (Gallus gallus)
        
        TFAP2C [nucleoplasm] (Gallus gallus)

Metabolism of proteins (Gallus gallus)

- Post-translational protein modification (Gallus gallus)
  - SUMOylation (Gallus gallus)
    - SUMO E3 ligases SUMOylate target proteins (Gallus gallus)
      - SUMOylation of transcription factors (Gallus gallus)
        
        SUMOylation of TFAP2C with SUMO1 (Gallus gallus)
        
        SUMO1:TFAP2C homodimer [nucleoplasm] (Gallus gallus)
        
        TFAP2C [nucleoplasm] (Gallus gallus)

External Reference Information

External Reference

UniProt:E1C5K7

Gene Names

TFAP2C

Reference Genes

BioGPS Gene:419327 TFAP2C

ENSEMBL:ENSGALG00000007690

KEGG Gene (Gallus gallus):419327 TFAP2C

Monarch:419327 TFAP2C

NCBI Gene:419327 TFAP2C

Reference Transcript

RefSeq:XM_417497.5 TFAP2C

Other Identifiers

419327

GO:0000003

GO:0000978

GO:0001227

GO:0001228

GO:0003674

GO:0003677

GO:0003700

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0006355

GO:0008150

GO:0008584

GO:0009058

GO:0034641

GO:0040029

GO:0043226

GO:0045944

GO:0048856

GO:1990837

GT_A_87_P070856

GgaAffx.22330.1.S1_at

Participates

as a component of

SUMO1:TFAP2C homodimer [nucleoplasm] (Gallus gallus)

Other forms of this molecule

TFAP2C [cytosol]

TFAP2C [nucleoplasm]

Inferred From

monoSUMO1-K10-TFAP2C [nucleoplasm] (Homo sapiens)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 10 (in Homo sapiens)

Coordinate

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

XP_417497.2

OpenTargets

ENSG00000087510

Ensembl

ENSGALT00000012465, ENSGALG00000007690, ENSGALP00000012451

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