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VCL [cytosol]
Stable Identifier
R-GGA-350753
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
VCL, P12003
Locations in the PathwayBrowser
Expand all
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Response to elevated platelet cytosolic Ca2+ (Gallus gallus)
Platelet degranulation (Gallus gallus)
Release of platelet cytosolic components (Gallus gallus)
Platelet releasate cytosolic proteins [cytosol] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
Muscle contraction (Gallus gallus)
Smooth Muscle Contraction (Gallus gallus)
ATP Hydrolysis By Myosin (Gallus gallus)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Gallus gallus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Gallus gallus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
Calcium Binds Caldesmon (Gallus gallus)
Calcium Bound Myosin Actin Complex [plasma membrane] (Gallus gallus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
Inactive Myosin Actin Contractile Complex [plasma membrane] (Gallus gallus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
Myosin Binds ATP (Gallus gallus)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Gallus gallus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Gallus gallus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
Release Of ADP From Myosin (Gallus gallus)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Gallus gallus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
Calcium Bound Myosin Actin Complex [plasma membrane] (Gallus gallus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
MAP2K and MAPK activation (Gallus gallus)
Dissociation of RAS:RAF complex (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
MAP2Ks and MAPKs bind to the activated RAF complex (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
MAP2Ks phosphorylate MAPKs (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
RAF phosphorylates MAP2K dimer (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
VCL [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:P12003
Gene Names
VCL
Reference Genes
BioGPS Gene:396422 VCL
ENSEMBL:ENSGALG00000005079
ENSEMBL:ENSGALG00010022474.1 VCL
ENSEMBL:ENSGALG00015009482 VCL
KEGG Gene (Gallus gallus):396422 VCL
Monarch:396422 VCL
NCBI Gene:396422 VCL
Reference Transcript
RefSeq:XM_015288203.1 VCL
RefSeq:NM_205441.1 VCL
Other Identifiers
396422
GO:0001725
GO:0002009
GO:0002102
GO:0002162
GO:0003779
GO:0005198
GO:0005515
GO:0005737
GO:0005739
GO:0005743
GO:0005856
GO:0005886
GO:0005903
GO:0005911
GO:0005912
GO:0005915
GO:0005916
GO:0005925
GO:0005927
GO:0007155
GO:0008013
GO:0008092
GO:0015629
GO:0016020
GO:0017166
GO:0030018
GO:0030032
GO:0030154
GO:0030334
GO:0031594
GO:0031625
GO:0032991
GO:0034330
GO:0034333
GO:0034394
GO:0042383
GO:0042803
GO:0042995
GO:0043034
GO:0043226
GO:0043297
GO:0044291
GO:0045294
GO:0045296
GO:0048675
GO:0048856
GO:0048870
GO:0051015
GO:0051371
GO:0051393
GO:0051893
GO:0061826
GO:0070161
GO:0090136
GO:0090636
GO:0090637
GO:0097110
GO:0098723
GO:1903140
GO:1904702
GO:1990357
GT_A_87_P016585
GT_A_87_P080426
GT_A_87_P122463
Gga.15976.1.S1_at
Gga.698.1.S1_at
Gga.698.1.S2_at
Participates
as a component of
integrin:cytoskeletal adhesion complex [plasma membrane] (Gallus gallus)
Vinculin bound to PIP2 [plasma membrane] (Gallus gallus)
as a member of
Platelet releasate cytosolic proteins [cytosol] (Gallus gallus)
Other forms of this molecule
VCL [specific granule lumen]
VCL [secretory granule lumen]
VCL [extracellular region]
VCL [ficolin-1-rich granule lumen]
Inferred From
VCL [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_015143689.1
,
NP_990772.1
OpenTargets
ENSG00000035403
Ensembl
ENSGALP00010033042
,
ENSGALT00010054688
,
ENSGALG00010022474
PRO
P12003
PDB
1T01
,
1QKR
,
1U6H
,
1ZW2
,
1ZVZ
,
3ZDL
,
6NR7
,
3JBI
,
1ZW3
,
1XWJ
,
4E17
,
6FQ4
,
1ST6
,
2GDC
,
4E18
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26039
2
Tln1 [extracellular region]
(R-MMU-350693)
Tln1 [cytosol]
(R-MMU-350713)
0.766
5
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