pyruvate + CO2 + ATP => oxaloacetate + ADP + orthophosphate

Stable Identifier
R-GGA-353154
Type
Reaction [transition]
Species
Gallus gallus
Compartment
Synonyms
Carboxylation of pyruvate to form oxaloacetate
ReviewStatus
5/5
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Pyruvate carboxylase catalyzes the reaction of pyruvate, ATP, and bicarbonate to form oxaloacetate, ADP, and orthophosphate. The active form of the enzyme is a tetramer, with one molecule each of biotin and Mn++ associated with each protein monomer. The reaction requires Mg++. Acetyl CoA is an allosteric activator of pyruvate carboxylase; the reaction does not proceed to a significant extent in its absence (Keech and Utter 1963; Scrutton and Utter 1967; Jitrapakdee et al. 2002).
Literature References
PubMed ID Title Journal Year
12150961 Molecular cloning and domain structure of chicken pyruvate carboxylase

Jitrapakdee, S, Khew-Goodall, Y, Cassady, AI, Wallace, JC, Nezic, MG

Biochem Biophys Res Commun 2002
6024765 Pyruvate carboxylase. IX. Some properties of the activation by certain acyl derivatives of coenzyme A

Utter, MF, Scrutton, MC

J Biol Chem 1967
14063280 Pyruvate carboxylase. II. Properties

Utter, MF, Keech, DB

J Biol Chem 1963
Participants
Participates
Catalyst Activity

pyruvate carboxylase activity of PYC [mitochondrial matrix]

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