Recruitment of repair factors to form the preincision complex

Stable Identifier
R-GGA-353476
Type
Reaction [binding]
Species
Gallus gallus
Compartment
nucleoplasm
ReviewStatus
5/5
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Recruitment of repair factors to form the preincision complex
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Binding of XP-C:RAD23B complex to the damaged site on the DNA substrate is followed by recruitment of XP-A and the RPA heterotrimer, initiating formation of the incision complex. This includes a serial assembly of the remainder of the NER (nucleotide excision repair) machinery consisting of TFIIH, XPG, SNM1 family proteins etc. The action of DNA helicases in the TFIIH complex partially denatures the DNA template generating a bubble structure and exposing a fragment of ssDNA containing the lesion for endonuclease activity. The subsequent events involving, formation of an active incision complex around the bubble structure by specific NER endonucleases and leading to the excision of ~27 30 bp of damaged ssDNA are not well characterized in chicken.
Literature References
PubMed ID Title Journal Year
15572677 DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation

Matsushita, N, Yamazoe, M, Takata, M, Buerstedde, JM, Takeda, S, Agematsu, K, Arakawa, H, Kimura, M, Ishiai, M, Namikoshi, K, Yamamoto, K

Mol Cell Biol 2004
1764072 Molecular cloning of human XPAC gene homologs from chicken, Xenopus laevis and Drosophila melanogaster

Okada, Y, Tanaka, K, Shimamoto, T, Kohno, K

Biochem Biophys Res Commun 1991
12773817 cDNA cloning of the chicken DDB1 gene encoding the p127 subunit of damaged DNA-binding protein

Nikaido, O, Fu, D, Wakasugi, M, Matsunaga, T, Ishigaki, Y

Genes Genet Syst 2003
15642098 Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis

Blagodatski, A, Plachy, J, Fiedler, P, Hayashizaki, Y, Bezzubov, Y, Koter, M, Kutter, S, Kierzek, AM, Carninci, P, Buerstedde, JM, Kostovska, D, Arakawa, H, Zaim, J, Caldwell, RB

Genome Biol 2005
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Authored
Saxena, A  (2008-07-07)
Reviewed
Borowiec, JA  (2009-04-24)
Created
Saxena, A  (2008-06-12)
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