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phospho-p-Y397-PTK2 [cytosol]
Stable Identifier
R-GGA-354068
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
Q00944
Locations in the PathwayBrowser
Expand all
Developmental Biology (Gallus gallus)
Nervous system development (Gallus gallus)
Axon guidance (Gallus gallus)
EPH-Ephrin signaling (Gallus gallus)
EPHB-mediated forward signaling (Gallus gallus)
Recruitment of p190RhoGEF to p-FAK (Gallus gallus)
EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Gallus gallus)
EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Gallus gallus)
EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Gallus gallus)
EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
Netrin-1 signaling (Gallus gallus)
DCC mediated attractive signaling (Gallus gallus)
Phosphorylation of DCC by Fyn (Gallus gallus)
NTN1:DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Gallus gallus)
NTN1:DCC oligomer:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Gallus gallus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
Autophosphorylation of PTK2 at Y397 (Gallus gallus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
Phosphorylation of pPTK2 by SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
Autophosphorylation of PTK2 at Y397 (Gallus gallus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
Phosphorylation of pPTK2 by SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
Signaling by Nuclear Receptors (Gallus gallus)
ESR-mediated signaling (Gallus gallus)
Extra-nuclear estrogen signaling (Gallus gallus)
PTK2 autophosphorylates downstream of EGFR (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by MET (Gallus gallus)
MET promotes cell motility (Gallus gallus)
MET activates PTK2 signaling (Gallus gallus)
MET phosphorylates PTK2 (Gallus gallus)
HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
PTK2 autophosphorylates (Gallus gallus)
HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
p-Y397-PTK2 binds SRC (Gallus gallus)
HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
PTK2 autophosphorylates (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
SRC-1 binds p-Y397-PTK2 (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
SRC-1 phosphorylates PTK2-beta (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
SRC-1 phosphorylates p-Y397-PTK2 (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
Src kinases phosphorylate VAV (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:Q00944
Reference Genes
ENSEMBL:ENSGALG00000031741
KEGG Gene (Gallus gallus):396416
Reference Transcript
RefSeq:NM_205435.1
Participates
as a component of
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Gallus gallus)
EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
NTN1:DCC oligomer:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
Other forms of this molecule
phospho-pY-PTK2 [cytosol]
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
phospho-p-Y194,Y397-PTK2 [cytosol]
phospho-p-5Y-PTK2 [cytosol]
phospho-p-5Y,S732-PTK2 [cytosol]
phospho-p-6Y,S732-PTK2 [cytosol]
PTK2(773-1052) [cytosol]
PTK2(1-772) [cytosol]
PTK2 [cytosol]
phospho-p-6Y-PTK2 [cytosol]
Inferred From
p-Y397-PTK2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 397 (in Homo sapiens)
Coordinate
397
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_990766.1
IntEnz
2.7.10.2
PRO
Q00944
PDB
1PV3
,
2J0L
,
2J0M
,
4D5H
,
1KTM
,
6TY4
,
6TY3
,
4D4R
,
2JKK
,
4D5K
,
6CB0
,
2JKM
,
4D4S
,
2L6F
,
4BRX
,
2JKO
,
6GCR
,
3ZDT
,
2L6H
,
2L6G
,
2AEH
,
4C7T
,
2JKQ
,
4D4V
,
4D55
,
1QVX
,
6GCX
,
6GCW
,
4D4Y
,
2J0J
,
2AL6
,
4CYE
,
2J0K
,
4D58
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q00944
11
phospho-pY-PTK2 [cytosol]
(R-GGA-9632393)
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-GGA-8874613)
phospho-p-Y194,Y397-PTK2 [cytosol]
(R-GGA-8874600)
phospho-p-5Y-PTK2 [cytosol]
(R-GGA-5218711)
phospho-p-5Y,S732-PTK2 [cytosol]
(R-GGA-5229006)
phospho-p-6Y,S732-PTK2 [cytosol]
(R-GGA-5218694)
PTK2(773-1052) [cytosol]
(R-GGA-202829)
PTK2(1-772) [cytosol]
(R-GGA-202827)
PTK2 [cytosol]
(R-GGA-201621)
phospho-p-Y397-PTK2 [cytosol]
(R-GGA-354068)
phospho-p-6Y-PTK2 [cytosol]
(R-GGA-354128)
0.656
3
UniProt:P61157 ACTR3
1
ARP3 [cytosol]
(R-BTA-419940)
0.612
5
UniProt:P49024 PAXI
0.609
2
UniProt:P08581 MET
7
MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-8875181)
MonoUb-K,p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8875180)
p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8874689)
p-Y1349,Y1356-MET [plasma membrane]
(R-HSA-6807032)
p-Y1234,Y1235,Y1356-MET [plasma membrane]
(R-HSA-6807014)
MET [plasma membrane]
(R-HSA-419603)
p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-6806973)
0.602
5
UniProt:P00523 SRC
9
SRC [cytosol]
(R-GGA-9628701)
phospho-p-Y419-SRC [cytosol]
(R-GGA-8964276)
MyrG-SRC [plasma membrane]
(R-GGA-8876922)
Src [cytosol]
(R-GGA-3928468)
SRC-1 [plasma membrane]
(R-GGA-65043)
phospho-p-Y419-SRC [cytosol]
(R-GGA-377592)
phospho-MyrG,p-Y530-SRC [plasma membrane]
(R-GGA-377598)
phospho-MyrG-p-Y419-SRC [plasma membrane]
(R-GGA-1810408)
SRC-2 [cytosol]
(R-GGA-191648)
0.589
3
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