Reactome | Nsl1/DC31 [cytosol]

Nsl1/DC31 [cytosol]

Stable Identifier

R-GGA-375309

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

NSL1, Q1T766

Locations in the PathwayBrowser

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Cell Cycle (Gallus gallus)

- Cell Cycle Checkpoints (Gallus gallus)
  - Mitotic Spindle Checkpoint (Gallus gallus)
    - Amplification of signal from the kinetochores (Gallus gallus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Gallus gallus)
        
        MAD2 associates with the Mad1 kinetochore complex (Gallus gallus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Gallus gallus)
        
        Mad1:kinetochore complex [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
        
        Mad1:kinetochore complex [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Gallus gallus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Gallus gallus)
        
        Mad1:kinetochore complex [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
        
        Mad1 binds kinetochore (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
        
        Mad1:kinetochore complex [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
        
        Release of activated MAD2 from kinetochores (Gallus gallus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Gallus gallus)
        
        Mad1:kinetochore complex [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
        
        Mad1:kinetochore complex [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
- Cell Cycle, Mitotic (Gallus gallus)
  - M Phase (Gallus gallus)
    - Mitotic Metaphase and Anaphase (Gallus gallus)
      - Mitotic Anaphase (Gallus gallus)
        
        Separation of Sister Chromatids (Gallus gallus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Gallus gallus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
    - Mitotic Prometaphase (Gallus gallus)
      - EML4 and NUDC in mitotic spindle formation (Gallus gallus)
        
        EML4 recruits NUDC to mitotic spindle (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
      - Resolution of Sister Chromatid Cohesion (Gallus gallus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Gallus gallus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
        
        Kinetochore assembly (Gallus gallus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Gallus gallus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Gallus gallus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
  - Signaling by Rho GTPases (Gallus gallus)
    - RHO GTPase Effectors (Gallus gallus)
      - RHO GTPases Activate Formins (Gallus gallus)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Gallus gallus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        KMN network [cytosol] (Gallus gallus)
        
        Mis12 complex [cytosol] (Gallus gallus)
        
        Nsl1/DC31 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:Q1T766

Gene Names

Nsl1/DC31

Reference Genes

BioGPS Gene:421367 Nsl1/DC31

ENSEMBL:ENSGALG00000009814

ENSEMBL:ENSGALG00010019268.1 Nsl1/DC31

KEGG Gene (Gallus gallus):421367 Nsl1/DC31

Monarch:421367 Nsl1/DC31

NCBI Gene:421367 Nsl1/DC31

Reference Transcript

RefSeq:NM_001044646.1 Nsl1/DC31

Other Identifiers

421367

GO:0000070

GO:0000278

GO:0000444

GO:0000776

GO:0005634

GO:0005654

GO:0005694

GO:0007059

GO:0016607

GO:0043226

GO:0140014

GT_A_87_P051976

GgaAffx.6156.1.S1_at

Participates

as a component of

Mis12 complex [cytosol] (Gallus gallus)

Inferred From

NSL1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001038111.1

Ensembl

ENSGALP00010027763, ENSGALT00010046618, ENSGALG00010019268

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