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About
What is Reactome ?
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Team
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Release Calendar
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Our Logo
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Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
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phospho-MyrG,p-Y530-SRC [plasma membrane]
Stable Identifier
R-GGA-377598
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
plasma membrane
Synonyms
P00523
Locations in the PathwayBrowser
Expand all
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
Activated integrin alphaIIb beta3 binds SHC1 (Gallus gallus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Clustering of Integrin alphaIIb beta3 complexes (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Inactive (p-Y530)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3 activation (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Release of CSK from SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Inactive (p-Y530)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Gallus gallus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
SHC1 dissociates from integrin alphaIIb beta3 (Gallus gallus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
Activated integrin alphaIIb beta3 binds SHC1 (Gallus gallus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Clustering of Integrin alphaIIb beta3 complexes (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Inactive (p-Y530)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3 activation (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Release of CSK from SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Inactive (p-Y530)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Gallus gallus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
SHC1 dissociates from integrin alphaIIb beta3 (Gallus gallus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
MAP2K and MAPK activation (Gallus gallus)
Dissociation of RAS:RAF complex (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
MAP2Ks and MAPKs bind to the activated RAF complex (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
MAP2Ks phosphorylate MAPKs (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
RAF phosphorylates MAP2K dimer (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by EGFR (Gallus gallus)
GAB1 signalosome (Gallus gallus)
Sustained activation of SRC kinase by SHP2 (Gallus gallus)
p-Y-PXN:CSK:MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
External Reference Information
External Reference
UniProt:P00523 SRC
Gene Names
SRC
Chain
initiator methionine:, chain:2-533
Reference Genes
BioGPS Gene:396442 SRC
KEGG:gga:396442 SRC
Monarch:396442 SRC
NCBI Gene:396442 SRC
UCSC:P00523 SRC
Reference Transcript
RefSeq:XM_015296348.1 SRC
RefSeq:NM_205457.2 SRC
Participates
as a component of
Integrin alphaIIb beta3:Inactive (p-Y530)-SRC [plasma membrane] (Gallus gallus)
p-Y-PXN:CSK:MyrG,p-Y530-SRC [plasma membrane] (Gallus gallus)
p-Y530-SRC:CSK [cytosol] (Gallus gallus)
Other forms of this molecule
SRC-2 [cytosol]
phospho-MyrG-p-Y419-SRC [plasma membrane]
SRC-1 [plasma membrane]
phospho-p-Y419-SRC [cytosol]
Src [cytosol]
MyrG-SRC [plasma membrane]
SRC [cytosol]
phospho-p-Y419-SRC [cytosol]
Inferred From
MyrG,p-Y530-SRC [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 530 (in Homo sapiens)
Coordinate
530
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
N-myristoylglycine at 2 (in Homo sapiens)
Coordinate
2
PsiMod Name
N-myristoylglycine [MOD:00068]
PsiMod Definition
A protein modification that effectively converts a glycine residue to N-myristoylglycine.
Cross References
RefSeq
NP_990788.2
,
XP_015151834.1
ZINC - Investigational
SRC_CHICK
ZINC - FDA approved
SRC_CHICK
ZINC - Substances
SRC_CHICK
ZINC target
P00523
PRO
P00523
ZINC - Predictions - Purchasable
SRC_CHICK
PDB
3QLG
,
3D7T
,
7PW0
,
3U51
,
7A31
,
7PVY
,
3EN4
,
7A3A
,
7A36
,
4RTY
,
7A37
,
1RLP
,
6XX3
,
3FJ5
,
3LOK
,
5D11
,
6XX4
,
2QI8
,
6XVM
,
4JZ3
,
4AGW
,
3F3T
,
3TZ7
,
4JZ4
,
7NER
,
2QQ7
,
3G6H
,
4OMN
,
7D5O
,
5OB2
,
7PVW
,
5OAV
,
3EN7
,
4QT7
,
5SYS
,
7A34
,
7D57
,
7A39
,
4OMQ
,
7AH3
,
7A35
,
7A3D
,
5TEH
,
6HVE
,
1RLQ
,
4YBK
,
5ECA
,
8K79
,
1PRL
,
5BMM
,
3F3W
,
5D12
,
1F1W
,
2HWO
,
6XVO
,
4LE9
,
3OF0
,
3EL8
,
4HVV
,
1P13
,
5XP5
,
7NES
,
3DQX
,
1F2F
,
4OMM
,
6L8L
,
5K9I
,
2OIQ
,
3SVV
,
7PVX
,
4LGG
,
4OMO
,
3TZ9
,
3EN6
,
7A33
,
3F6X
,
7PVZ
,
5I11
,
4RTW
,
7A3C
,
7A30
,
5T0P
,
6WIW
,
4YBJ
,
3UQF
,
4RTZ
,
6XX2
,
6HVF
,
1NLO
,
5D10
,
3UQG
,
1PRM
,
3F3V
,
5EC7
,
6XVN
,
4FIC
,
5J5S
,
4O2P
,
3DQW
,
3G5D
,
3EL7
,
4HVU
,
5XP7
,
1SRL
,
3G6G
,
5OB1
,
4OML
,
4RTU
,
4DGG
,
4LGH
,
3QLF
,
7A32
,
4OMP
,
3EN5
,
4RTV
,
7A3B
,
4MCV
,
3D7U
,
4RTX
,
7A3E
,
7A38
,
7WF5
,
4U5J
,
1NLP
,
3U4W
,
5SWH
,
6XX5
,
3F3U
,
2HWP
,
3TZ8
,
3OEZ
,
4HVW
,
2QLQ
,
3GEQ
,
7NET
,
1SRM
,
2PTK
,
5OB0
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P41240 CSK
2
CSK [cytosol]
(R-HSA-203776)
CSK [plasma membrane]
(R-HSA-180499)
0.719
7
UniProt:P18433 PTPRA
1
PTPRA [plasma membrane]
(R-HSA-388755)
0.59
4
UniProt:Q00944
11
phospho-p-6Y-PTK2 [cytosol]
(R-GGA-354128)
phospho-p-Y397-PTK2 [cytosol]
(R-GGA-354068)
PTK2 [cytosol]
(R-GGA-201621)
PTK2(1-772) [cytosol]
(R-GGA-202827)
PTK2(773-1052) [cytosol]
(R-GGA-202829)
phospho-p-6Y,S732-PTK2 [cytosol]
(R-GGA-5218694)
phospho-p-5Y,S732-PTK2 [cytosol]
(R-GGA-5229006)
phospho-p-5Y-PTK2 [cytosol]
(R-GGA-5218711)
phospho-pY-PTK2 [cytosol]
(R-GGA-9632393)
phospho-p-Y194,Y397-PTK2 [cytosol]
(R-GGA-8874600)
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-GGA-8874613)
0.589
3
UniProt:Q9QWY8-1 ASAP1
0.581
3
UniProt:O88703
1
HCN2 [plasma membrane]
(R-MMU-977502)
0.581
5
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.564
2
UniProt:Q90738 AFAP1
0.564
3
UniProt:Q9Y4D1 DAAM1
1
DAAM1 [cytosol]
(R-HSA-351052)
0.556
3
UniProt:P61980
2
Hnrnpk [nucleoplasm]
(R-RNO-4570532)
Hnrnpk [nucleoplasm]
(R-RNO-71945)
0.544
2
UniProt:Q9QWY8-2 ASAP1
0.544
2
UniProt:P18052
1
PTPRA [plasma membrane]
(R-MMU-388755)
0.525
2
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