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Mitotic checkpoint complex [cytosol]
Stable Identifier
R-GGA-377882
Type
Complex
Species
Gallus gallus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Gallus gallus)
Cell Cycle Checkpoints (Gallus gallus)
Mitotic Spindle Checkpoint (Gallus gallus)
Amplification of signal from the kinetochores (Gallus gallus)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Gallus gallus)
MAD2 associates with the Mad1 kinetochore complex (Gallus gallus)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Gallus gallus)
Mad1:kinetochore complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Mad1:kinetochore complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
MAD2 converted to an inhibitory state via interaction with Mad1 (Gallus gallus)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Gallus gallus)
Mad1:kinetochore complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Mad1 binds kinetochore (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Mad1:kinetochore complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Release of activated MAD2 from kinetochores (Gallus gallus)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Gallus gallus)
Mad1:kinetochore complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Mad1:kinetochore complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Gallus gallus)
Inactivation of APC/C via direct inhibition of the APC/C complex (Gallus gallus)
Binding of the MCC complex to the APC/C complex (Gallus gallus)
MCC:APC/C complex [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Formation of the MCC complex (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Cell Cycle, Mitotic (Gallus gallus)
M Phase (Gallus gallus)
Mitotic Metaphase and Anaphase (Gallus gallus)
Mitotic Anaphase (Gallus gallus)
Separation of Sister Chromatids (Gallus gallus)
ESPL1 (Separase) cleaves centromeric cohesin (Gallus gallus)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Mitotic Prometaphase (Gallus gallus)
EML4 and NUDC in mitotic spindle formation (Gallus gallus)
EML4 recruits NUDC to mitotic spindle (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Resolution of Sister Chromatid Cohesion (Gallus gallus)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Gallus gallus)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Kinetochore assembly (Gallus gallus)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
PP2A-B56 dephosphorylates centromeric cohesin (Gallus gallus)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Phosphorylation of cohesin by PLK1 at centromeres (Gallus gallus)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Regulation of mitotic cell cycle (Gallus gallus)
APC/C-mediated degradation of cell cycle proteins (Gallus gallus)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Gallus gallus)
APC/C:Cdc20 mediated degradation of mitotic proteins (Gallus gallus)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Gallus gallus)
APC-Cdc20 mediated degradation of Nek2A (Gallus gallus)
Association of Nek2A with MCC:APC/C (Gallus gallus)
MCC:APC/C complex [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Nek2A:MCC:APC/C complex [cytosol] (Gallus gallus)
MCC:APC/C complex [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Degradation of multiubiquitinated Nek2A (Gallus gallus)
MCC:APC/C complex [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Multiubiquitinated Nek2A [cytosol] (Gallus gallus)
Nek2A:MCC:APC/C complex [cytosol] (Gallus gallus)
MCC:APC/C complex [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Multiubiquitination of Nek2A (Gallus gallus)
Multiubiquitinated Nek2A [cytosol] (Gallus gallus)
Nek2A:MCC:APC/C complex [cytosol] (Gallus gallus)
MCC:APC/C complex [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Nek2A:MCC:APC/C complex [cytosol] (Gallus gallus)
MCC:APC/C complex [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Gallus gallus)
Association of Cyclin A with the APC/C (Gallus gallus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Gallus gallus)
MCC:APC/C complex [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
MCC:APC/C complex [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Degradation multiubiquitinated Cyclin A (Gallus gallus)
MCC:APC/C complex [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Gallus gallus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Gallus gallus)
MCC:APC/C complex [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Gallus gallus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Gallus gallus)
MCC:APC/C complex [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
MCC:APC/C complex [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Gallus gallus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Gallus gallus)
MCC:APC/C complex [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Gallus gallus)
MCC:APC/C complex [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Regulation of APC/C activators between G1/S and early anaphase (Gallus gallus)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Gallus gallus)
Inactivation of APC/C via direct inhibition of the APC/C complex (Gallus gallus)
Binding of the MCC complex to the APC/C complex (Gallus gallus)
MCC:APC/C complex [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Formation of the MCC complex (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
Signaling by Rho GTPases (Gallus gallus)
RHO GTPase Effectors (Gallus gallus)
RHO GTPases Activate Formins (Gallus gallus)
AURKB phosphorylates DIAPH2-2 at kinetochores (Gallus gallus)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Mitotic checkpoint complex [cytosol] (Gallus gallus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
BUB1B [cytosol]
(Gallus gallus)
BUB3 [cytosol]
(Gallus gallus)
CDC20 [cytosol]
(Gallus gallus)
MAD2L1 [cytosol]
(Gallus gallus)
Participates
as an input of
Binding of the MCC complex to the APC/C complex (Gallus gallus)
as an output of
Formation of the MCC complex (Gallus gallus)
as a component of
MCC:APC/C complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
Inferred From
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol]
(Homo sapiens)
Mitotic checkpoint complex [cytosol]
(Homo sapiens)
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