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active PDGF-AA dimer [extracellular region]
Stable Identifier
R-GGA-380761
Type
Complex
Species
Gallus gallus
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Response to elevated platelet cytosolic Ca2+ (Gallus gallus)
Platelet degranulation (Gallus gallus)
Exocytosis of platelet alpha granule contents (Gallus gallus)
Platelet alpha granule contents [extracellular region] (Gallus gallus)
PDGF dimer [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
RAS GEFs [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by PDGF (Gallus gallus)
Autophosphorylation of PDGF alpha receptors (Gallus gallus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Gallus gallus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
Phospho PDGF alpha receptor:PDGF dimers [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
Downstream signal transduction (Gallus gallus)
Activated PLC gamma dissociates from the PDGF receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
Activation of Src (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
Crk binds to the active PDGF receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
GRB2:SOS1 complex binds to the active receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
Nck binds to the active PDGF receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PI3-kinase binds to the active receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PLC-gamma binds to the active receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
Phosphorylation of PLCgamma by PDGFR (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
SH2 domain of Src binds to the active receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
SHP2 binds to the active receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
STAT binds to the active receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
p130Cas and C3G bind PDGFR bound Crk (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF dimer binds two receptors simultaneously (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF:PDGF receptor dimer [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGF-AA clevage by Furin (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGFRs bind type I TKI (Gallus gallus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Gallus gallus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
active PDGF-AA dimer [extracellular region] (Gallus gallus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
PDGF-A (L) [extracellular region]
(Gallus gallus)
Participates
as a member of
PDGF dimer [extracellular region] (Gallus gallus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Gallus gallus)
as an output of
PDGF-AA clevage by Furin (Gallus gallus)
Inferred From
PDGF A homodimer [extracellular region]
(Homo sapiens)
active PDGF-AA dimer [extracellular region]
(Homo sapiens)
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