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phospho CD28:B7-1/B7-2 [plasma membrane]
Stable Identifier
R-GGA-388777
Type
Complex
Species
Gallus gallus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Costimulation by the CD28 family (Gallus gallus)
CD28 co-stimulation (Gallus gallus)
CD28 dependent PI3K/Akt signaling (Gallus gallus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
CD28:PI3K [plasma membrane] (Gallus gallus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
PI3K binds CD28 (Gallus gallus)
CD28:PI3K [plasma membrane] (Gallus gallus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
CD28 dependent Vav1 pathway (Gallus gallus)
Activation of Cdc42 by pVav1 (Gallus gallus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Gallus gallus)
CD28:Grb2 [plasma membrane] (Gallus gallus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
Activation of Rac1 by pVav1 (Gallus gallus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Gallus gallus)
CD28:Grb2 [plasma membrane] (Gallus gallus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
Activation of Vav1 (Gallus gallus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Gallus gallus)
CD28:Grb2 [plasma membrane] (Gallus gallus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Gallus gallus)
CD28:Grb2 [plasma membrane] (Gallus gallus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
Grb2 binds CD28 (Gallus gallus)
CD28:Grb2 [plasma membrane] (Gallus gallus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
Gads binds CD28 (Gallus gallus)
CD28:GRAP2 [plasma membrane] (Gallus gallus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
Phosphorylation of CD28 (Gallus gallus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
CD28:PI3K [plasma membrane] (Gallus gallus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
CD28:PI3K [plasma membrane] (Gallus gallus)
phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
B7-1 homodimer/ B7-2 [plasma membrane]
(Gallus gallus)
x 2
FYN,LCK [cytosol]
(Gallus gallus)
Phospho CD28 homodimer [plasma membrane]
(Gallus gallus)
Participates
as an input of
Gads binds CD28 (Gallus gallus)
Grb2 binds CD28 (Gallus gallus)
PI3K binds CD28 (Gallus gallus)
as a component of
CD28:GRAP2 [plasma membrane] (Gallus gallus)
CD28:Grb2 [plasma membrane] (Gallus gallus)
CD28:PI3K [plasma membrane] (Gallus gallus)
as an output of
Phosphorylation of CD28 (Gallus gallus)
Inferred From
phospho CD28:B7-1/B7-2 [plasma membrane]
(Homo sapiens)
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