Reactome | FBXL3 [cytosol]

FBXL3 [cytosol]

Stable Identifier

R-GGA-391289

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

FBXL3, A0A3Q2U3I7

Locations in the PathwayBrowser

Expand all

Immune System (Gallus gallus)

- Adaptive Immune System (Gallus gallus)
  - Class I MHC mediated antigen processing & presentation (Gallus gallus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Gallus gallus)
      - Interaction of E3 with substrate and E2-Ub complex (Gallus gallus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
      - Polyubiquitination of substrate (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
        
        E3:Ub:substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
      - Release of E3 from polyubiquitinated substrate (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
      - Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
        
        E3:Ub:substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)

Metabolism of proteins (Gallus gallus)

- Post-translational protein modification (Gallus gallus)
  - Neddylation (Gallus gallus)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Gallus gallus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Gallus gallus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Gallus gallus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Gallus gallus)
        
        CRL E3 ubiquitin ligases [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
      - CRL E3 ubiquitin ligases [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Gallus gallus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Gallus gallus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Gallus gallus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Gallus gallus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL3 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A3Q2U3I7

Gene Names

FBXL3

Reference Genes

ENSEMBL:ENSGALG00000048716

ENSEMBL:ENSGALG00010000784.1 FBXL3

Other Identifiers

428048

GO:0005515

GO:0005634

GO:0005829

GO:0019005

GO:0030163

GO:0031146

GO:0043153

GO:0043226

GT_A_87_P017442

Gga.7145.1.S1_at

GgaAffx.10839.1.S1_at

Participates

as a member of

F-box protein [cytosol] (Gallus gallus)

Inferred From

FBXL3 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000005812

Ensembl

ENSGALP00010000913, ENSGALG00010000784, ENSGALT00010001712

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