Interaction of Src family kinases with p-EPHs

Stable Identifier
R-GGA-3928579
Type
Reaction [binding]
Species
Gallus gallus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Interaction of Src family kinases with p-EPHs
Src family kinases (SFKs) are one of the important components of EPH receptor-mediated axon guidance. Inhibition of SFK-mediated phosphorylation in retinal axons, abolishes EPHA-mediated repulsion in stripe and growth cone collapse assays (Knoll & Drescher 2004). Several members of the Src family, including SRC, FYN, LYN and YES, are expressed widely in the same places as EPH receptors. Autophosphorylated tyrosines in the juxtamembrane region of the EPH receptors have been shown to be critical for the association of the SRC and FYN SH2 domain (Ellis et al. 1996, Zisch et al. 1998). These SFKs are involved in the phosphorylation of RhoGEF ephexin1 and cortactin (Knoll & Drescher 2004). This event is deduced on the basis of experimental evidence from chicken assay studies (Knoll & Drescher 2004).

Specifically, activated EPHA4 was shown to form a complex with FYN and LYN kinases (Prevost et al. 2002).

Literature References
PubMed ID Title Journal Year
8622893 A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn

Walls, E, Kasmi, F, Ellis, C, Ganju, P, Reith, AD, Panayotou, G

Oncogene 1996
9632142 Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region

Pasquale, EB, Chong, LD, Zisch, AH, Kalo, MS

Oncogene 1998
Participants
Input
Output
Orthologous Events
p-EPHs bind SRC,FYN,YES,LYN (Homo sapiens)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)
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