Reactome | LPAR1 [plasma membrane]

LPAR1 [plasma membrane]

Stable Identifier

R-GGA-419354

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

LPAR1, B0FMV4

Locations in the PathwayBrowser

Expand all

Signal Transduction (Gallus gallus)

- Signaling by GPCR (Gallus gallus)
  - GPCR downstream signalling (Gallus gallus)
    - G alpha (i) signalling events (Gallus gallus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5 [plasma membrane] (Gallus gallus)
        
        LPAR1 [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5 [plasma membrane] (Gallus gallus)
        
        LPAR1 [plasma membrane] (Gallus gallus)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5 [plasma membrane] (Gallus gallus)
        
        LPAR1 [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5 [plasma membrane] (Gallus gallus)
        
        LPAR1 [plasma membrane] (Gallus gallus)
      - The Ligand:GPCR:Gi complex dissociates (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5 [plasma membrane] (Gallus gallus)
        
        LPAR1 [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5 [plasma membrane] (Gallus gallus)
        
        LPAR1 [plasma membrane] (Gallus gallus)
    - G alpha (q) signalling events (Gallus gallus)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5 [plasma membrane] (Gallus gallus)
        
        LPAR1 [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5 [plasma membrane] (Gallus gallus)
        
        LPAR1 [plasma membrane] (Gallus gallus)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5 [plasma membrane] (Gallus gallus)
        
        LPAR1 [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5 [plasma membrane] (Gallus gallus)
        
        LPAR1 [plasma membrane] (Gallus gallus)
      - The Ligand:GPCR:Gq complex dissociates (Gallus gallus)
        
        GPCRs that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5 [plasma membrane] (Gallus gallus)
        
        LPAR1 [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5 [plasma membrane] (Gallus gallus)
        
        LPAR1 [plasma membrane] (Gallus gallus)
  - GPCR ligand binding (Gallus gallus)
    - Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
      - Lysosphingolipid and LPA receptors (Gallus gallus)
        
        LPA-binding receptors bind LPA (Gallus gallus)
        
        LPAR1,2,3,5 [plasma membrane] (Gallus gallus)
        
        LPAR1 [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Gallus gallus)
        
        LPAR1,2,3,5 [plasma membrane] (Gallus gallus)
        
        LPAR1 [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:B0FMV4

Gene Names

LPAR1

Reference Genes

BioGPS Gene:427339 LPAR1

ENSEMBL:ENSGALG00000015729

ENSEMBL:ENSGALG00010005828.1 LPAR1

KEGG Gene (Gallus gallus):427339 LPAR1

Monarch:427339 LPAR1

NCBI Gene:427339 LPAR1

Reference Transcript

Other Identifiers

427339

GO:0004930

GO:0005737

GO:0005768

GO:0005886

GO:0007165

GO:0007186

GO:0007189

GO:0007200

GO:0009986

GO:0016020

GO:0019222

GO:0022008

GO:0023052

GO:0030154

GO:0031410

GO:0043226

GO:0048856

GO:0060089

GO:0070915

GT_A_87_P022069

GT_A_87_P055616

Gga.19720.1.S1_at

Gga.9756.1.S1_at

Participates

as a member of

LPAR1,2,3,5 [plasma membrane] (Gallus gallus)

Inferred From

LPAR1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_015136096.1, XP_015136095.1, NP_001108554.1

OpenTargets

ENSG00000198121

Ensembl

ENSGALT00010013881, ENSGALG00010005828, ENSGALP00010008193

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