Formation of PPAT tetramers

Stable Identifier
R-GGA-420906
Type
Reaction [binding]
Species
Gallus gallus
Compartment
cytosol
ReviewStatus
5/5
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Formation of PPAT tetramers
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Biochemical characterization of purified avian PPAT (chicken (Hartman 1963) and pigeon (Caskey et al. 1964; Rowe et al. 1970)) suggests that while both PPAT dimers and tetramers are catalytically active in vitro, PPRP allosterically activates PPAT while AMP and GMP allosterically inactivate it, and activity changes are associated with changes in enzyme multimerization. The specific reaction annotated here, association of active PPAT dimers to form relatively inactive tetramers, its inhibition by PRPP, and its stimulation by AMP and GMP, are inferred from studies of the homologous human enzyme (Holmes et al. 1973).
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Event Information
Reverse Reaction
Formation of PPAT dimers (Gallus gallus)
This event is regulated
Negatively by
Regulator
PRPP [cytosol]
Positively by
Regulator
GMP [cytosol]
Regulator
AMP [cytosol]
Created
D'Eustachio, P  (2009-05-14)
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