protoporphyrin IX + Fe++ => heme + 2 H+

Stable Identifier
R-GGA-421447
Type
Reaction [transition]
Species
Gallus gallus
Compartment
mitochondrial matrix
ReviewStatus
5/5
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protoporphyrin IX + Fe++ => heme + 2 H+
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
FECH (ferrochelatase) in the mitochondrial matrix catalyzes the reaction of protoporphyrin IX and ferrous iron to form heme, releasing two H+. The active form of FECH is a dimer with one iron-sulfur cluster bound per monomer (Day et al. 1998).
Literature References
PubMed ID Title Journal Year
9808757 Cloning and characterization of Gallus and Xenopus ferrochelatases: presence of the [2Fe-2S] cluster in nonmammalian ferrochelatase

Day, AL, Parsons, BM, Dailey, HA

Arch Biochem Biophys 1998
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Catalyst Activity

ferrochelatase activity of FECH dimer [mitochondrial matrix]

Physical Entity
FECH dimer [mitochondrial matrix] (Gallus gallus)
Activity
ferrochelatase activity (GO:0004325)
Authored
D'Eustachio, P  (2009-05-19)
Created
D'Eustachio, P  (2009-05-19)
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