All serine residues mentioned above were empirically defined for human IRF3. Multiple sequence alignment of human, mouse and chicken IRF3 by ClustalW showed similarity in the C-terminal domain and the following chicken residues are predicted to be involved in chicken IRF3 activation:
McWhirter, SM, Maniatis, T, Harrison, SC, Panne, D
Fujita, T, Inagaki, F, Takahashi, K, Yoneyama, M, Mori, M, Ito, T
Nishida, E, Fukuda, M, Suhara, W, Fujita, T, Fukuhara, Y, Yoneyama, M
protein serine/threonine kinase activity of ds viral RNA : TLR3 : TICAM1 : IKK epsilon complex [endosome membrane]
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