Reactome | IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88

IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88

Stable Identifier

R-GGA-433864

Type

Reaction [binding]

Species

Gallus gallus

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88

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In mammals activated IRAK4 phosphorylates both IRAK1 and IRAK2. Activated IRAK1 and IRAK2 in turn induce NFkB and AP-1 intracellular signaling cascades mediated by TRAF6.

Bioinformatic analysis reveals no evidence of IRAK1 in the chicken genome. It is possible that the chicken TLR pathway utilizes only IRAK-2, which shares 47% amino acid sequence identity with human IRAK2.

Literature References

PubMed ID	Title	Journal	Year
18438411	Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2 Kumagai, Y, Kawai, T, Takeuchi, O, Saitoh, T, Matsushita, K, Sato, S, Akira, S, Matsui, K, Kato, H, Kawagoe, T	Nat Immunol	2008
19539094	The avian Toll-Like receptor pathway--subtle differences amidst general conformity Lloyd, AT, Downing, T, Cormican, P, Bradley, D, O'Farrelly, C, Connell, SJ	Dev Comp Immunol	2009