LPS binding to Toll like receptor 4 results in dimerization of the TLR4 associated with LY96

Stable Identifier
R-GGA-434058
Type
Reaction [binding]
Species
Gallus gallus
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In mammals, LPS stimulation results in the formation of TLR4:LY96 complex (Park et al. 2009). Chicken TLR4:LY96 complex was also shown to mediate responsiveness to LPS (Keestra et al 2008). However, the authors suggested that differences in amino acid composition may results in the species-specific interaction between chTLR4 and chLY96.
Literature References
PubMed ID Title Journal Year
19627256 Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins

O'Neill, LA, Carpenter, S

Biochem J 2009
18768894 Unique properties of the chicken TLR4/MD-2 complex: selective lipopolysaccharide activation of the MyD88-dependent pathway

Keestra, AM, van Putten, JP

J Immunol 2008
15373971 Ligand-dependent Toll-like receptor 4 (TLR4)-oligomerization is directly linked with TLR4-signaling

Matsumoto, F, Miyake, K, Tanimura, N, Yamada, T, Kusumoto, S, Akashi, S, Fukase, K, Kosugi, A, Saitoh, S

J Endotoxin Res 2004
Participants
Participates
Authored
Reviewed
Created
Cite Us!