Reactome | viral dsRNA:TRL3:TICAM1 activates RIP1

viral dsRNA:TRL3:TICAM1 activates RIP1

Stable Identifier

R-GGA-434097

Type

Reaction [binding]

Species

Gallus gallus

Related Species

Infectious bronchitis virus

Compartment

endosome membrane, cytosol

ReviewStatus

5/5

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RIP1 is recruited to the activated TLR receptor by binding to TICAM1(TRIF) via its RHIM motif, followed by its polyubiquitination. Polyubiquitination is possibly mediated by TRAF6 that is also recruited to TICAM1 (Cusson-Hermance N et al. 2005). Other E3-ubiquitin ligases - cIAP1 and cIAP2 - have been reported to promote polyubiquitination of RIP proteins (Bertrand MJM et al. 2011).

RIP3 was shown to inhibit TRIF-induced NFkB activation in dose-dependent manner when overexpressed in HEK293T cells by competing with TRIF to bind RIP1 (Meylan E et al. 2004). Chicken RIP1 protein, confirmed by transcript evidedence, shows 48% amino acid sequence identity with human RIP1.

Literature References

PubMed ID	Title	Journal	Year
16115877	Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation Fitzgerald, KA, Cusson-Hermance, N, Khurana, S, Kelliher, MA, Lee, TH	J Biol Chem	2005