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Activation and dimerization of c-JUN in the nucleus
Stable Identifier
R-GGA-438026
Type
Reaction [transition]
Species
Gallus gallus
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Innate Immune System (Gallus gallus)
Toll-like receptors (TLR) cascades (Gallus gallus)
TLR15 cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
MAPK activation in TLR cascade (Gallus gallus)
Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
Activation and dimerization of c-JUN in the nucleus (Gallus gallus)
TLR2 subfamily cascade (Gallus gallus)
MyD88:TIRAP-dependent cascade initiated on plasma membrane (Gallus gallus)
NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
MAPK activation in TLR cascade (Gallus gallus)
Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
Activation and dimerization of c-JUN in the nucleus (Gallus gallus)
TLR21 cascade (Gallus gallus)
MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
MAPK activation in TLR cascade (Gallus gallus)
Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
Activation and dimerization of c-JUN in the nucleus (Gallus gallus)
TLR3 cascade (Gallus gallus)
TRAF6 mediated induction of proinflammatory cytokines (Gallus gallus)
MAPK activation in TLR cascade (Gallus gallus)
Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
Activation and dimerization of c-JUN in the nucleus (Gallus gallus)
TLR4 cascade (Gallus gallus)
MyD88:TIRAP-dependent cascade initiated on plasma membrane (Gallus gallus)
NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
MAPK activation in TLR cascade (Gallus gallus)
Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
Activation and dimerization of c-JUN in the nucleus (Gallus gallus)
TLR5 cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
MAPK activation in TLR cascade (Gallus gallus)
Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
Activation and dimerization of c-JUN in the nucleus (Gallus gallus)
TLR7 cascade (Gallus gallus)
MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
MAPK activation in TLR cascade (Gallus gallus)
Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
Activation and dimerization of c-JUN in the nucleus (Gallus gallus)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Shortly after phosphorylation JNKs are translocated to nucleus where they associate and activate their target transcription factors.
Literature References
PubMed ID
Title
Journal
Year
18793328
c-Jun expression, activation and function in neural cell death, inflammation and repair
Raivich, G
J Neurochem
2008
Participants
Input
x 4
ATP [nucleoplasm]
x 2
c-JUN [nucleoplasm]
(Gallus gallus)
Output
activated c-JUN dimer [nucleoplasm]
(Gallus gallus)
x 4
ADP [nucleoplasm]
Participates
as an event of
Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
Catalyst Activity
JUN kinase activity of phosphorylated JNK homologs [nucleoplasm]
Physical Entity
phosphorylated JNK homologs [nucleoplasm]
(Gallus gallus)
Activity
JUN kinase activity (GO:0004705)
This event is regulated
Negatively by
Regulator
MAPK phosphatases [nucleoplasm]
(Gallus gallus)
Inferred From
Activated JNKs phosphorylate c-JUN (Homo sapiens)
Authored
Shamovsky, V (2009-09-22)
Reviewed
D'Eustachio, P (2010-05-23)
Created
Shamovsky, V (2009-09-22)
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