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IL5 [extracellular region]
Stable Identifier
R-GGA-447159
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
extracellular region
Synonyms
IL5, F1P2P6
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-2 family signaling (Gallus gallus)
Interleukin receptor SHC signaling (Gallus gallus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Phosphorylated SHC recruits GRB2:SOS1 (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Phosphorylated SHC1 recruits GRB2:GAB2 (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Phosphorylated SHC1 recruits SHIP (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Gallus gallus)
14-3-3 zeta binding allows recruitment of PI3K (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Activation of STAT5a/b by JAK2 (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Interleukin receptor SHC signaling (Gallus gallus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Phosphorylated SHC recruits GRB2:SOS1 (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Phosphorylated SHC1 recruits GRB2:GAB2 (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Phosphorylated SHC1 recruits SHIP (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Interleukin-5 is a homodimer (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Interleukin-5 receptor alpha subunit binds Interleukin-5 (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
JAK2 is phosphorylated, activated (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Recruitment of SHC1 is mediated by Y593 of the common beta chain (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
SHP1 and SHP2 bind the common beta chain (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593)-Bc [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
STAT5 is recruited by JAK2 (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
The receptor is activated (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
High affinity binding complexes of interleukin receptors using the Common beta chain [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Tyrosine kinases phosphorylate the receptor (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Tyrosine kinases that phosphorylate the Common beta chain [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
p-S585-IL3RB binds 14-3-3 proteins (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
p-STAT5 dissociates from the receptor complex (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
Signal Transduction (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
RAS GEFs [plasma membrane] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Gallus gallus)
IL5 homodimer:IL5RA [plasma membrane] (Gallus gallus)
IL5 homodimer [extracellular region] (Gallus gallus)
IL5 [extracellular region] (Gallus gallus)
External Reference Information
External Reference
UniProt:F1P2P6
Gene Names
IL5
Reference Genes
ENSEMBL:ENSGALG00000023822
ENSEMBL:ENSGALG00010016298.1 IL5
Other Identifiers
474360
GO:0002376
GO:0005125
GO:0005137
GO:0005576
GO:0005615
GO:0006955
GO:0007165
GO:0008083
GO:0023052
GO:0048018
GO:0098772
GT_A_87_P037223
Participates
as an input of
Interleukin-5 is a homodimer (Gallus gallus)
as a component of
IL5 homodimer [extracellular region] (Gallus gallus)
Inferred From
IL5 [extracellular region]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000113525
Ensembl
ENSGALP00010022620
,
ENSGALG00010016298
,
ENSGALT00010039186
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