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What is Reactome ?
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K63-Ub [cytosol]
Stable Identifier
R-GGA-450143
Type
Set [DefinedSet]
Species
Gallus gallus
Compartment
cytosol
Synonyms
K63-ubiquitin
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-17 signaling (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
TNFR2 non-canonical NF-kB pathway (Gallus gallus)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Innate Immune System (Gallus gallus)
Alpha-protein kinase 1 signaling pathway (Gallus gallus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Gallus gallus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Gallus gallus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 10 (TLR10) Cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
IRAK2 mediated activation of TAK1 complex (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Toll Like Receptor 2 (TLR2) Cascade (Gallus gallus)
Toll Like Receptor TLR1:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
IRAK2 mediated activation of TAK1 complex (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Toll Like Receptor TLR6:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
IRAK2 mediated activation of TAK1 complex (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Toll Like Receptor 3 (TLR3) Cascade (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88-independent TLR4 cascade (Gallus gallus)
TRIF (TICAM1)-mediated TLR4 signaling (Gallus gallus)
IKK complex recruitment mediated by RIP1 (Gallus gallus)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Gallus gallus)
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Activation of TAK1 complex bound to activated TLR4 complex (Gallus gallus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Phosphorylated TAK1 leaves activated TLR receptor complex (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
IRAK2 mediated activation of TAK1 complex (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Toll Like Receptor 5 (TLR5) Cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
IRAK2 mediated activation of TAK1 complex (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Toll Like Receptor 9 (TLR9) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Deubiquitination (Gallus gallus)
Josephin domain DUBs (Gallus gallus)
ATXN3 deubiquitinates polyUb-PARK2 (Gallus gallus)
PolyUb [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
ATXN3 family cleave Ub chains (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
PARK2 autoubiquitinates (Gallus gallus)
PolyUb [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Metalloprotease DUBs (Gallus gallus)
BRISC complex deubiquitinates NLRP3 (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
PSMD14 cleaves K63-linked ubiquitin (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
STAMBPL1 is a deubiquitinase (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Ovarian tumor domain proteases (Gallus gallus)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Ub-specific processing proteases (Gallus gallus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
USP10 deubiquitinates SNX3, CFTR (Gallus gallus)
PolyUb [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
USP13 deubiquitinates BECN1,USP10 (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
USP18 deubiquitinates TAK1:TAB1 (Gallus gallus)
PolyUb [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
USP19 deubiquitinates RNF123 (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
USP20, USP33 deubiquitinate ADRB2 (Gallus gallus)
PolyUb [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
USP33 deubiquitinates CCP110,ARRB (Gallus gallus)
PolyUb [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
USP4 deubiquitinate TRAF2,TRAF6 (Gallus gallus)
PolyUb [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
USP5 cleaves polyubiquitin (Gallus gallus)
USP5:PolyUb [cytosol] (Gallus gallus)
PolyUb [cytosol] (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Death Receptor Signaling (Gallus gallus)
TNF signaling (Gallus gallus)
TNFR1-induced NF-kappa-B signaling pathway (Gallus gallus)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Gallus gallus)
K63polyUb [cytosol] (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Transport of small molecules (Gallus gallus)
Plasma lipoprotein assembly, remodeling, and clearance (Gallus gallus)
Plasma lipoprotein clearance (Gallus gallus)
VLDLR internalisation and degradation (Gallus gallus)
MYLIP dimer ubiquitinates VLDLR on Lys-839 (Gallus gallus)
K63-Ub [cytosol] (Gallus gallus)
Participants
members
K63-ubiquitin (RPS27A) [cytosol]
(Gallus gallus)
K63-ubiquitin (UBB 1) [cytosol]
(Gallus gallus)
UBB [cytosol]
(Gallus gallus)
Participates
as an output of
STAMBPL1 is a deubiquitinase (Gallus gallus)
PSMD14 cleaves K63-linked ubiquitin (Gallus gallus)
ATXN3 family cleave Ub chains (Gallus gallus)
as an input of
MYLIP dimer ubiquitinates VLDLR on Lys-839 (Gallus gallus)
as a repeated unit of
K63polyUb [cytosol] (Gallus gallus)
Inferred From
K63-Ub [cytosol]
(Homo sapiens)
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