pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex

Stable Identifier
R-GGA-451463
Type
Reaction [binding]
Species
Gallus gallus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex
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Polyubiquitinated TRAF6 activates TAK1 by binding to the ubiquitin receptor TAB2 (also known as MAP3K7IP2). This binding leads to autophosphorylation and activation of TAK1.
Literature References
PubMed ID Title Journal Year
17496917 Ubiquitin-mediated activation of TAK1 and IKK

Xu, M, Adhikari, A, Chen, ZJ

Oncogene 2007
19675569 Direct activation of protein kinases by unanchored polyubiquitin chains

Adhikari, A, Zeng, W, Chen, ZJ, Pineda, G, Sun, L, Chen, X, Jiang, X, Xia, ZP

Nature 2009
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Output
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as an event of
Inferred From
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Homo sapiens)
Authored
Shamovsky, V  (2010-01-05)
Reviewed
D'Eustachio, P  (2010-10-16)
Created
Shamovsky, V  (2010-01-05)
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