Reactome | activated MEK2 binds ERK2

activated MEK2 binds ERK2

Stable Identifier

R-GGA-451482

Type

Reaction [binding]

Species

Gallus gallus

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Innate Immune System (Gallus gallus)

- Toll-like receptors (TLR) cascades (Gallus gallus)
  - TLR15 cascade (Gallus gallus)
    - MyD88 cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        activated MEK2 binds ERK2 (Gallus gallus)
  - TLR2 subfamily cascade (Gallus gallus)
    - MyD88:TIRAP-dependent cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        activated MEK2 binds ERK2 (Gallus gallus)
  - TLR21 cascade (Gallus gallus)
    - MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        activated MEK2 binds ERK2 (Gallus gallus)
  - TLR3 cascade (Gallus gallus)
    - TRAF6 mediated induction of proinflammatory cytokines (Gallus gallus)
      - MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        activated MEK2 binds ERK2 (Gallus gallus)
  - TLR4 cascade (Gallus gallus)
    - MyD88:TIRAP-dependent cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        activated MEK2 binds ERK2 (Gallus gallus)
  - TLR5 cascade (Gallus gallus)
    - MyD88 cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        activated MEK2 binds ERK2 (Gallus gallus)
  - TLR7 cascade (Gallus gallus)
    - MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        activated MEK2 binds ERK2 (Gallus gallus)

General

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Activated mammalian MEK1/2 is a serine/threonine kinase, which phosphorylates and activates ERK1/2. ERK1/2 is then translocates to the nucleus and activates transcription factors.

Chicken MEK2 showes 93% amino acid sequence identity to human MEK2. Multiple sequence alignment of human, mouse and chicken MEK2 by ClustalW allows to predict that the following chicken residues are involved in chicken MEK2 activation: Ser220 and Ser224 that are corresponding to human residues Ser222 and Ser226.

Literature References

PubMed ID	Title	Journal	Year
18669607	Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-kappaB signaling pathways Kogut, MH, Genovese, KJ, Kaiser, P, He, H	Innate Immun	2008
17045653	Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1 Kogut, MH, Genovese, KJ, He, H	Mol Immunol	2007

Participants

Input

Output

phospho MEK2 : ERK2 [cytosol] (Gallus gallus)

Participates

as an event of

ERK activation (Gallus gallus)

Inferred From

MAP2K2 binds MAPK1 (Homo sapiens)

Authored

Shamovsky, V (2009-09-22)

Reviewed

D'Eustachio, P (2010-10-16)

Created

Shamovsky, V (2010-01-05)