Reactome | Dissociation of phospho ERK2 :phospho MEK2 complex

Dissociation of phospho ERK2 :phospho MEK2 complex

Stable Identifier

R-GGA-451505

Type

Reaction [dissociation]

Species

Gallus gallus

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Innate Immune System (Gallus gallus)

- Toll-like receptors (TLR) cascades (Gallus gallus)
  - TLR15 cascade (Gallus gallus)
    - MyD88 cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        Dissociation of phospho ERK2 :phospho MEK2 complex (Gallus gallus)
  - TLR2 subfamily cascade (Gallus gallus)
    - MyD88:TIRAP-dependent cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        Dissociation of phospho ERK2 :phospho MEK2 complex (Gallus gallus)
  - TLR21 cascade (Gallus gallus)
    - MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        Dissociation of phospho ERK2 :phospho MEK2 complex (Gallus gallus)
  - TLR3 cascade (Gallus gallus)
    - TRAF6 mediated induction of proinflammatory cytokines (Gallus gallus)
      - MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        Dissociation of phospho ERK2 :phospho MEK2 complex (Gallus gallus)
  - TLR4 cascade (Gallus gallus)
    - MyD88:TIRAP-dependent cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        Dissociation of phospho ERK2 :phospho MEK2 complex (Gallus gallus)
  - TLR5 cascade (Gallus gallus)
    - MyD88 cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        Dissociation of phospho ERK2 :phospho MEK2 complex (Gallus gallus)
  - TLR7 cascade (Gallus gallus)
    - MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        Dissociation of phospho ERK2 :phospho MEK2 complex (Gallus gallus)

General

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Dissociation of phospho ERK2 :phospho MEK2 complex

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

MEK-ERK pathways are considered to be highly conserved. Their involvement in up-regulation of the inflammatory response has been demonstrated in mammals and chicken (Johnson GL and Lapadat R 2002; Kogut M et al 2008).

In this model we assume that chicken MEK-ERK mediators behave like their human counterparts.

Literature References

PubMed ID	Title	Journal	Year
18669607	Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-kappaB signaling pathways Kogut, MH, Genovese, KJ, Kaiser, P, He, H	Innate Immun	2008
17045653	Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1 Kogut, MH, Genovese, KJ, He, H	Mol Immunol	2007

Participants

Input

phospho ERK2 : phospho MEK2 [cytosol] (Gallus gallus)

Output

Participates

as an event of

ERK activation (Gallus gallus)

Inferred From

Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Homo sapiens)

Authored

Shamovsky, V (2009-09-22)

Reviewed

D'Eustachio, P (2010-10-16)

Created

Shamovsky, V (2010-01-05)