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BIRC8 [cytosol]
Stable Identifier
R-GGA-50849
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
XIAP, A0A8V0YRF2
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Gallus gallus)
Cell junction organization (Gallus gallus)
Cell-cell junction organization (Gallus gallus)
Adherens junctions interactions (Gallus gallus)
Activation of STAT3 by cadherin engagement (Gallus gallus)
Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination (Gallus gallus)
RAC1,(CDC42) Ubiquitin Ligase [cytosol] (Gallus gallus)
(CDC42 E3 ubiquitin ligases) [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
(RAC1 E3 ubiquitin ligases) [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
Programmed Cell Death (Gallus gallus)
Apoptosis (Gallus gallus)
Intrinsic Pathway for Apoptosis (Gallus gallus)
Apoptotic factor-mediated response (Gallus gallus)
Cytochrome c-mediated apoptotic response (Gallus gallus)
Activation of caspases through apoptosome-mediated cleavage (Gallus gallus)
Cleavage of Procaspase-3 by the apoptosome (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
Cleavage of Procaspase-7 by the apoptosome (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
Formation of apoptosome (Gallus gallus)
Regulation of the apoptosome activity (Gallus gallus)
XIAP binds CASP9 (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
XIAP:apoptosome [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
SMAC, XIAP-regulated apoptotic response (Gallus gallus)
SEPT4 binds XIAP (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
SEPT4 dimer:XIAP [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
SMAC (DIABLO) binds to IAPs (Gallus gallus)
SMAC (DIABLO) binds XIAP (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
DIABLO dimer:XIAP [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
SMAC binds XIAP:Caspase-7 (Gallus gallus)
DIABLO:XIAP:Caspase-7 [cytosol] (Gallus gallus)
XIAP:Caspase-7 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
XIAP:Caspase-7 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes (Gallus gallus)
Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Gallus gallus)
DIABLO dimer:XIAP [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
DIABLO:XIAP:Caspase-7 [cytosol] (Gallus gallus)
XIAP:Caspase-7 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
XIAP binds CASP3 (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
DIABLO:XIAP:Caspase-3 [cytosol] (Gallus gallus)
XIAP:Caspase-3 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
XIAP:Caspase-3 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
XIAP binds CASP7 (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
XIAP:Caspase-7 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
Regulated Necrosis (Gallus gallus)
RIPK1-mediated regulated necrosis (Gallus gallus)
Regulation of necroptotic cell death (Gallus gallus)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Death Receptor Signaling (Gallus gallus)
TNF signaling (Gallus gallus)
Regulation of TNFR1 signaling (Gallus gallus)
K63polyUb-RIPK1 is deubiquitinated (Gallus gallus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Gallus gallus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Gallus gallus)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Gallus gallus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
TNFR1-induced NF-kappa-B signaling pathway (Gallus gallus)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
PTEN Regulation (Gallus gallus)
Regulation of PTEN localization (Gallus gallus)
PTEN undergoes monoubiquitination (Gallus gallus)
XIAP,NEDD4 [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
Regulation of PTEN stability and activity (Gallus gallus)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Gallus gallus)
NEDD4,STUB1,WWP2 and XIAP [cytosol] (Gallus gallus)
BIRC8 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A8V0YRF2
Gene Names
BIRC8
Reference Genes
BioGPS Gene:395280 BIRC8
ENSEMBL:ENSGALG00010013281.1
KEGG:gga:395280 BIRC8
Monarch:395280 BIRC8
NCBI Gene:395280 BIRC8
UCSC:A0A8V0YRF2 BIRC8
Reference Transcript
RefSeq:NM_001396142.1 BIRC8
RefSeq:XM_040698693.2 BIRC8
RefSeq:NM_001396141.1 BIRC8
RefSeq:XM_046939884.1 BIRC8
RefSeq:XM_046939883.1 BIRC8
RefSeq:XM_046939882.1 BIRC8
RefSeq:NM_204588.3 BIRC8
Other Identifiers
395280
GO:0003824
GO:0004842
GO:0004869
GO:0005634
GO:0005737
GO:0006511
GO:0006974
GO:0007249
GO:0010804
GO:0016740
GO:0019805
GO:0031398
GO:0032480
GO:0032481
GO:0032496
GO:0038066
GO:0042742
GO:0042802
GO:0042981
GO:0043066
GO:0043123
GO:0043124
GO:0046330
GO:0051402
GO:0060785
GO:0061630
GO:0070427
GO:0070431
GO:0070534
GO:0090263
GO:0097039
GO:0097194
GO:0098542
GO:0098772
GO:0120283
GO:0140096
GO:1902530
GT_A_87_P055286
Gga.104.1.S1_at
Participates
as a candidate of
(RAC1 E3 ubiquitin ligases) [cytosol] (Gallus gallus)
(CDC42 E3 ubiquitin ligases) [cytosol] (Gallus gallus)
XIAP,NEDD4 [cytosol] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
as a member of
NEDD4,STUB1,WWP2 and XIAP [cytosol] (Gallus gallus)
as an input of
SEPT4 binds XIAP (Gallus gallus)
SMAC (DIABLO) binds XIAP (Gallus gallus)
XIAP binds CASP3 (Gallus gallus)
XIAP binds CASP7 (Gallus gallus)
XIAP binds CASP9 (Gallus gallus)
as a component of
SEPT4 dimer:XIAP [cytosol] (Gallus gallus)
XIAP:apoptosome [cytosol] (Gallus gallus)
XIAP:Caspase-7 [cytosol] (Gallus gallus)
DIABLO dimer:XIAP [cytosol] (Gallus gallus)
XIAP:Caspase-3 [cytosol] (Gallus gallus)
This entity regulates
Negatively
Cleavage of Procaspase-7 by the apoptosome
(Gallus gallus)
Cleavage of Procaspase-3 by the apoptosome
(Gallus gallus)
Other forms of this molecule
BIRC8 [nucleoplasm]
BIRC8 [cytosol]
Inferred From
XIAP [cytosol]
(Homo sapiens)
XIAP [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_046795840.1
,
NP_989919.2
,
XP_046795839.1
,
XP_046795838.1
,
XP_040554627.1
,
NP_001383070.1
,
NP_001383071.1
ENSEMBL
ENSGALG00010013281
,
ENSGALT00010031940
,
ENSGALP00010018734
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