TLR2-1 : TLR1-2 heterodimer binds to its ligand

Stable Identifier
R-GGA-517850
Type
Reaction [binding]
Species
Gallus gallus
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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TLR2-1 : TLR1-2 heterodimer binds to its ligand
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Higuchi et al. (2008) and Keestra et al. (2007) demonstrated that chTLR2 subfamily members distinguish between their ligands by combinational events and combined expression of chTLR2 and chTLR1 isoforms is needed for TLR receptor function. Both groups studied the chTLR2 signaling by NF-kB reporter assay using human cells (HEK293 or HeLa 57A) transfected with chTLRs 1 or 2. Keestra et al. (2007) reported that only TLR2 type 2 was able to form functional heterodimer with TLR16 (TLR1 type 1). In contrast, Higuchi et al. (2008) showed on HEK293 cells that both isoforms of chTLR2 form functional TLR2 complexes with chTLR1 type 1 or 2.

Based on the data of those studies:

  • chTLR1 type 2 with either chTLR2 type 1 or 2 formed cooperative sensors of peptidoglycan (PGN), diacylated bacterial lypoproteins (BLP), macrophage-activating lipopeptide 2 kDa (Malp-2) and triacylated BLP
  • the combination of chTLR2-1 and chTLR1-1 recognized triacylated BLP and synthetic triacylated lipopeptide - Pam3.
  • chTLR2 -2 combined with chTLR1-1(TLR16) cooperatively responded to both diacylated and triacylated bacterial lypoproteins.
Literature References
PubMed ID Title Journal Year
17614130 Combinational recognition of bacterial lipoproteins and peptidoglycan by chicken Toll-like receptor 2 subfamily

Matsumoto, M, Oshiumi, H, Funami, K, Shida, K, Higuchi, M, Suzuki, Y, Ishii, A, Matsuo, A, Seya, T, Shingai, M

Dev Comp Immunol 2008
17513760 The central leucine-rich repeat region of chicken TLR16 dictates unique ligand specificity and species-specific interaction with TLR2

Keestra, AM, de Zoete, MR, van Aubel, RA, van Putten, JP

J Immunol 2007
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Authored
Shamovsky, V  (2010-02-20)
Reviewed
D'Eustachio, P  (2010-10-16)
Created
Shamovsky, V  (2010-02-20)
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