Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
phospho-PTK2 [cytosol]
Stable Identifier
R-GGA-5229006
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
p-5Y,S732-PTK2, Q00944
Locations in the PathwayBrowser
Expand all
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Gallus gallus)
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2 [plasma membrane] (Gallus gallus)
phospho-PTK2 [cytosol] (Gallus gallus)
p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Gallus gallus)
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2 [plasma membrane] (Gallus gallus)
phospho-PTK2 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:Q00944
Gene Names
PTK2
Reference Genes
BioGPS Gene:396416 PTK2
ENSEMBL:ENSGALG00000031741
KEGG Gene (Gallus gallus):396416 PTK2
Monarch:396416 PTK2
NCBI Gene:396416 PTK2
Reference Transcript
RefSeq:NM_205435.1 PTK2
Other Identifiers
396416
GO:0000166
GO:0001525
GO:0002020
GO:0002376
GO:0003674
GO:0004198
GO:0004672
GO:0004713
GO:0004714
GO:0004715
GO:0005102
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005815
GO:0005856
GO:0005886
GO:0005925
GO:0005929
GO:0006464
GO:0006468
GO:0006508
GO:0006950
GO:0007010
GO:0007015
GO:0007155
GO:0007165
GO:0007169
GO:0007172
GO:0007173
GO:0007275
GO:0008150
GO:0008219
GO:0008233
GO:0008283
GO:0008284
GO:0009268
GO:0010812
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019899
GO:0021852
GO:0022607
GO:0030054
GO:0030154
GO:0030155
GO:0031234
GO:0031953
GO:0032092
GO:0034330
GO:0035994
GO:0036064
GO:0040011
GO:0042383
GO:0042802
GO:0042995
GO:0043167
GO:0043197
GO:0043226
GO:0044319
GO:0045087
GO:0046777
GO:0048471
GO:0048646
GO:0048856
GO:0048870
GO:0051894
GO:0060055
GO:0061098
GO:0065003
GO:1904237
GO:2000811
GT_A_87_P057091
GT_A_87_P105323
GT_A_87_P105328
GT_A_87_P122603
Gga.15614.1.S1_a_at
Gga.15614.1.S2_a_at
Gga.4725.1.S1_at
Participates
as a component of
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2 [plasma membrane] (Gallus gallus)
Other forms of this molecule
phospho-PTK2 [cytosol]
phospho-PTK2 [cytosol]
phospho-PTK2 [cytosol]
phospho-PTK2 [cytosol]
phospho-PTK2 [cytosol]
PTK2 [cytosol]
PTK2 [cytosol]
PTK2 [cytosol]
phospho-PTK2 [cytosol]
phospho-PTK2 [cytosol]
Inferred From
p-5Y,S732-PTK2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 397 (in Homo sapiens)
Coordinate
397
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 576 (in Homo sapiens)
Coordinate
576
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 577 (in Homo sapiens)
Coordinate
577
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 861 (in Homo sapiens)
Coordinate
861
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 925 (in Homo sapiens)
Coordinate
925
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O-phospho-L-serine at 732 (in Homo sapiens)
Coordinate
732
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_990766.1
OpenTargets
ENSG00000169398
IntEnz
2.7.10.2
Ensembl
ENSGALT00000072414
,
ENSGALP00000044406
,
ENSGALG00000031741
PRO
Q00944
PDB
6CB0
,
2JKQ
,
4D58
,
4D4Y
,
4D4V
,
4D55
,
2JKO
,
4D4S
,
2JKK
,
2JKM
,
4D4R
,
1QVX
,
2AL6
,
2J0M
,
2J0K
,
2L6G
,
6TY4
,
2J0L
,
2L6H
,
6TY3
,
2AEH
,
2J0J
,
2L6F
,
1KTM
,
4CYE
,
4BRX
,
6GCX
,
3ZDT
,
6GCW
,
4D5K
,
1PV3
,
4D5H
,
6GCR
,
4C7T
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q00944
11
phospho-PTK2 [cytosol]
(R-GGA-8874613)
phospho-PTK2 [cytosol]
(R-GGA-8874600)
phospho-PTK2 [cytosol]
(R-GGA-9632393)
phospho-PTK2 [cytosol]
(R-GGA-5218711)
phospho-PTK2 [cytosol]
(R-GGA-5229006)
phospho-PTK2 [cytosol]
(R-GGA-5218694)
PTK2 [cytosol]
(R-GGA-202829)
PTK2 [cytosol]
(R-GGA-202827)
PTK2 [cytosol]
(R-GGA-201621)
phospho-PTK2 [cytosol]
(R-GGA-354068)
phospho-PTK2 [cytosol]
(R-GGA-354128)
0.656
3
UniProt:P61157 ACTR3
1
ARP3 [cytosol]
(R-BTA-419940)
0.612
5
UniProt:P49024 PAXI
0.609
2
UniProt:P08581 MET
7
p-Y1234,Y1235,Y1356-MET [plasma membrane]
(R-HSA-6807014)
p-Y1349,Y1356-MET [plasma membrane]
(R-HSA-6807032)
MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-8875181)
MonoUb-K,p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8875180)
p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8874689)
MET [plasma membrane]
(R-HSA-419603)
p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-6806973)
0.602
5
UniProt:P00523 SRC
9
SRC [cytosol]
(R-GGA-9628701)
phospho-SRC [cytosol]
(R-GGA-8964276)
Src [cytosol]
(R-GGA-3928468)
SRC [plasma membrane]
(R-GGA-8876922)
SRC [plasma membrane]
(R-GGA-190535)
phospho-SRC [cytosol]
(R-GGA-377592)
phospho-SRC [plasma membrane]
(R-GGA-377598)
phospho-SRC [plasma membrane]
(R-GGA-1810408)
SRC [cytosol]
(R-GGA-191648)
0.589
3
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text