Reactome | ERCC8 [nucleoplasm]

ERCC8 [nucleoplasm]

Stable Identifier

R-GGA-52835

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

nucleoplasm

Synonyms

ERCC8, A0A3Q2UP36

Locations in the PathwayBrowser

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DNA Repair (Gallus gallus)

- Nucleotide Excision Repair (Gallus gallus)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Gallus gallus)
    - Dual incision in TC-NER (Gallus gallus)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Gallus gallus)
        
        TC-NER incision complex [nucleoplasm] (Gallus gallus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Gallus gallus)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)
        
        TC-NER pre-incision complex [nucleoplasm] (Gallus gallus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
      - ERCC5 and RPA bind TC-NER site (Gallus gallus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
    - Formation of TC-NER Pre-Incision Complex (Gallus gallus)
      - ERCC8 (CSA) binds stalled RNA Pol II (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
      - ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
      - UVSSA:USP7 deubiquitinates ERCC6 (Gallus gallus)
        
        TC-NER pre-incision complex [nucleoplasm] (Gallus gallus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Gallus gallus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Gallus gallus)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Gallus gallus)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Gallus gallus)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Gallus gallus)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
        
        ERCC8 [nucleoplasm] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A3Q2UP36

Gene Names

ERCC8

Reference Genes

BioGPS Gene:427153 ERCC8

ENSEMBL:ENSGALG00000014732

ENSEMBL:ENSGALG00010012669.1 ERCC8

Monarch:427153 ERCC8

NCBI Gene:427153 ERCC8

Reference Transcript

RefSeq:XM_424742.5 ERCC8

Other Identifiers

427153

GO:0000109

GO:0000209

GO:0005515

GO:0005634

GO:0006281

GO:0006283

GO:0030163

GO:0031464

GO:0036211

GO:0043161

GO:0043226

GO:0050896

GT_A_87_P024073

Gga.11058.1.S1_at

Participates

as a member of

DCAF protein [nucleoplasm] (Gallus gallus)

as a component of

ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)

Inferred From

ERCC8 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_424742.1

OpenTargets

ENSG00000049167

Ensembl

ENSGALG00010012669, ENSGALP00010017584, ENSGALT00010030314

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