p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21

Stable Identifier
R-GGA-532630
Type
Reaction [dissociation]
Species
Gallus gallus
Compartment
endosome membrane
ReviewStatus
5/5
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p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21
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There is little experimental data about mammalian IRAK2 mediated signaling. It is possible that phosphorylated IRAK2, like IRAK1, dissociates from upstream adapters such as MyD88 but leaves its interaction with the downstream adapter TRAF6 unaffected. Furthermore Keating et al. [2007] showed that IRAK2 can promote TRAF6 ubiquitination. Other studies [Wan et al 2009] detected IRAK2-TRAF6 interaction upon LPS stimulation.

In this reaction we assume that chicken IRAK2 behaves like its mammalian homolog IRAK2.

Literature References
PubMed ID Title Journal Year
14625308 Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling

Kollewe, C, Mackensen, AC, Neumann, D, Knop, J, Cao, P, Li, S, Wesche, H, Martin, MU

J Biol Chem 2004
Participants
Input
Output
Participates
as an event of
Inferred From
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)
Authored
Shamovsky, V  (2010-11-30)
Reviewed
D'Eustachio, P  (2010-12-06)
Created
Shamovsky, V  (2010-03-02)
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