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p-S218,S222 MAP2K1 dimer [cytosol]
Stable Identifier
R-GGA-5672703
Type
Complex
Species
Gallus gallus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
MAP2K and MAPK activation (Gallus gallus)
Dissociation of RAS:RAF complex (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
IL17RD binds p-2S MAP2Ks and MAPKs (Gallus gallus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Gallus gallus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
MAP2Ks phosphorylate MAPKs (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
RAF phosphorylates MAP2K dimer (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
RAF activation (Gallus gallus)
Phosphorylation of RAF (Gallus gallus)
RAF activating kinases [plasma membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by NTRKs (Gallus gallus)
Signaling by NTRK1 (TRKA) (Gallus gallus)
Signalling to ERKs (Gallus gallus)
Prolonged ERK activation events (Gallus gallus)
Frs2-mediated activation (Gallus gallus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Gallus gallus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
Dissociation of phosphorylated MAP2Ks and MAPKs (Gallus gallus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Gallus gallus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Gallus gallus)
p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
phospho-p-S218,S222-MAP2K1 [cytosol]
(Gallus gallus)
Participates
as a component of
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Gallus gallus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Gallus gallus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Gallus gallus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
as an input of
IL17RD binds p-2S MAP2Ks and MAPKs (Gallus gallus)
as an output of
Dissociation of phosphorylated MAP2Ks and MAPKs (Gallus gallus)
Dissociation of RAS:RAF complex (Gallus gallus)
as a candidate of
RAF activating kinases [plasma membrane] (Gallus gallus)
Inferred From
p-2S MAP2K homo/heterodimers [cytosol]
(Homo sapiens)
p-S218,S222 MAP2K1 dimer [cytosol]
(Homo sapiens)
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