Reactome | CTSZ [COPII-coated ER to Golgi transport vesicle]

CTSZ [COPII-coated ER to Golgi transport vesicle]

Stable Identifier

R-GGA-5689727

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

COPII-coated ER to Golgi transport vesicle

Synonyms

(Glc)3(GlcNAc)2(Man)9-CTSZ, A0A1D5PFA7

Locations in the PathwayBrowser

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Metabolism of proteins (Gallus gallus)

- Post-translational protein modification (Gallus gallus)
  - Asparagine N-linked glycosylation (Gallus gallus)
    - Transport to the Golgi and subsequent modification (Gallus gallus)
      - ER to Golgi Anterograde Transport (Gallus gallus)
        
        COPII-mediated vesicle transport (Gallus gallus)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Gallus gallus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Gallus gallus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        CTSZ [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        Nucleotide exchange on RAB1 (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        CTSZ [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        CTSZ [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        CTSZ [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        CTSZ [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        Vesicle budding (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        CTSZ [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)

Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - ER to Golgi Anterograde Transport (Gallus gallus)
    - COPII-mediated vesicle transport (Gallus gallus)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Gallus gallus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Gallus gallus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        CTSZ [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
      - Nucleotide exchange on RAB1 (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        CTSZ [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        CTSZ [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        CTSZ [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        CTSZ [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
      - Vesicle budding (Gallus gallus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Gallus gallus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
        
        CTSZ [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A1D5PFA7

Gene Names

CTSZ

Reference Genes

ENSEMBL:ENSGALG00000007462

ENSEMBL:ENSGALG00000007462.7 CTSZ

Participates

as a member of

glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)

Other forms of this molecule

CTSZ [Golgi lumen]

CTSZ [lysosomal lumen]

CTSZ [plasma membrane]

CTSZ [specific granule lumen]

CTSZ [extracellular region]

CTSZ [ficolin-1-rich granule lumen]

CTSZ [endoplasmic reticulum-Golgi intermediate compartment membrane]

CTSZ [endoplasmic reticulum lumen]

Inferred From

(Glc)3(GlcNAc)2(Man)9-CTSZ [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)

Modified Residues

Name

N4-(N-acetylamino)glucosyl-L-asparagine (N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue (ChEBI:59084)) at unknown position

Modification

N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-yl group (ChEBI:59084)

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Cross References

OpenTargets

ENSG00000101160

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